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European vaccine effort against hiv/aids - ii

Objective

HIV-1 and AIDS are spreading in Africa and Asia at unprecedented speed. A vaccine against HIV-1/AIDS is urgently needed. Vaccine candidates that show most promise in simian AIDS models are based on a prime-boost strategy, applying naked DNA or alphaviruses as prime and pox viruses as boost. The objectives of the EuroVac- II project are to demonstrate in a phase I trial of humans: firstly the ability of Semliki Forest virus (SFV) to prime anti-HIV immune responses, - compared to the attenuated poxvirus NYVAC -, using a recombinant gp140 protein boost; and secondly the ability of SFV priming, - using DNA priming as benchmark -, to improve the immune responses elicited by NYVAC + rgp140 vaccination. This design will provide conclusions concerning the relative immunogenicity of different prime-boost strategies. The HIV-1 genes used are recovered from a primary isolate belonging to HIV-1 subtype C, the most frequent cause of AIDS worldwide. The choice of genes (gag, pol, nef) other than envelope is based on the frequency of HIV-specific T-cell responses in long-term asymptomatic HIV infected individuals.

Funding Scheme

DEM - Demonstration contracts

Coordinator

KAROLINSKA INSTITUTE
Address
13,Nobels Väg 16
171 77 Stockholm
Sweden

Participants (12)

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Address
Meibergdreef 15
1105AZ Amsterdam
AVENTIS PASTEUR SA
France
Address
1541,Avenue Marcel Mérieux 1541
69280 Marcy-l'etoile
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Allte D'italie 46
69364 Lyon
COBRA THERAPEUTICS LTD
United Kingdom
Address
Stephenson Building, Science Park, Keele
ST5 5SP Newcastle
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Via Olgettina 58
20132 Milano
HUNTINGDON LIFE SCIENCES LTD
United Kingdom
Address
Wooley Road, Alconbury
PE28 4HS Huntingdon
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Du Cane Road
W12 0NN London
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue Koeberle 3 Adr 16 - Alsace
67000 Strasbourg
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Euston Road, 222
W1N 4AL London
TRANSGENE SA
France
Address
Rue Laurent Fries
67400 Illkirch Graffenstaden
UNIVERSITAET REGENSBURG
Germany
Address
11,Frans-joseph-strauss-allee 11
93053 Regensburg
UNIVERSITY OF LAUSANE
Switzerland
Address
Avenue De Beaumont 29 Hopital Beaumont
1011 Lausanne