European vaccine effort against hiv/aids - ii

Objective

HIV-1 and AIDS are spreading in Africa and Asia at unprecedented speed. A vaccine against HIV-1/AIDS is urgently needed. Vaccine candidates that show most promise in simian AIDS models are based on a prime-boost strategy, applying naked DNA or alphaviruses as prime and pox viruses as boost. The objectives of the EuroVac- II project are to demonstrate in a phase I trial of humans: firstly the ability of Semliki Forest virus (SFV) to prime anti-HIV immune responses, - compared to the attenuated poxvirus NYVAC -, using a recombinant gp140 protein boost; and secondly the ability of SFV priming, - using DNA priming as benchmark -, to improve the immune responses elicited by NYVAC + rgp140 vaccination. This design will provide conclusions concerning the relative immunogenicity of different prime-boost strategies. The HIV-1 genes used are recovered from a primary isolate belonging to HIV-1 subtype C, the most frequent cause of AIDS worldwide. The choice of genes (gag, pol, nef) other than envelope is based on the frequency of HIV-specific T-cell responses in long-term asymptomatic HIV infected individuals.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

DEM - Demonstration contracts

Coordinator

KAROLINSKA INSTITUTE

Address

13,Nobels Väg 16
171 77 Stockholm
Sweden

 

Participants (12)

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

Address

Meibergdreef 15
1105AZ Amsterdam

 

AVENTIS PASTEUR SA

France

Address

1541,Avenue Marcel Mérieux 1541
69280 Marcy-l'etoile

 

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Allte D'italie 46
69364 Lyon

 

COBRA THERAPEUTICS LTD

United Kingdom

Address

Stephenson Building, Science Park, Keele
ST5 5SP Newcastle

 

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

Address

Via Olgettina 58
20132 Milano

 

HUNTINGDON LIFE SCIENCES LTD

United Kingdom

Address

Wooley Road, Alconbury
PE28 4HS Huntingdon

 

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

Address

Du Cane Road
W12 0NN London

 

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Rue Koeberle 3 Adr 16 - Alsace
67000 Strasbourg

 

MEDICAL RESEARCH COUNCIL

United Kingdom

Address

Euston Road, 222
W1N 4AL London

 

TRANSGENE SA

France

Address

Rue Laurent Fries
67400 Illkirch Graffenstaden

 

UNIVERSITAET REGENSBURG

Germany

Address

11,Frans-joseph-strauss-allee 11
93053 Regensburg

 

UNIVERSITY OF LAUSANE

Switzerland

Address

Avenue De Beaumont 29 Hopital Beaumont
1011 Lausanne