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Microbiological and structural strategies for the diagnostic and epidemiology of pseudomonas aeruginosa infections (pseudomonas virulence)

Objective

Infections with Pseudomonas aerations are a major burden for human health and economy. This bacterium is an important cause for nosocomial (hospital acquired) infections, particularly in intensive care units, burns units, neonatal units, and wards housing leukaemia and other cancer patients. This proposal is a concerted effort to link medical and structural biology. The aims of this project are
i) to develop diagnostic tests based on DNA chip technology that allow surveillance and infection control;
ii) to identify the genomic and expression signatures of particularly virulent strains for future path typing of P. aerations;
iii) to produce crystal structures of active efflux systems of P. aerations involved in mechanism such as multidrug resistance. Efflux pump inhibitors combined with existing antibiotics could increase the susceptibility of P. oreganos to such
iv) to identify new virulence factors using the new host system c. elegant.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Faculté De Pharmacie - Université René Descartes,
75270 Paris
France

Participants (8)

BIOXTAL SARL
France
Address
Rue De L'alouette 16
59100 Roubaix
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
31,Chemin Joseph Aiguier 31
13402 Marseille
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
HANNOVER MEDICAL SCHOOL
Germany
Address
Carl-neuberg-strasse 1
30625 Hannover
PHARMALEADS S.A.
France
Address
Avenue De Bouvines 16
75011 Paris
UNIVERSITE DE BORDEAUX I
France
Address
Enscpb Avenue Pey-berland
33402 Talence
UNIVERSITE DE PARIS V 'RENÉ DESCARTES'
France
Address
Avenue De L'observatoire 4
75270 Paris
UNIVERSITY OF GENEVA
Switzerland
Address
1,Avenue De Champel 9
1211 Geneve