Infections with Pseudomonas aerations are a major burden for human health and economy. This bacterium is an important cause for nosocomial (hospital acquired) infections, particularly in intensive care units, burns units, neonatal units, and wards housing leukaemia and other cancer patients. This proposal is a concerted effort to link medical and structural biology. The aims of this project are
i) to develop diagnostic tests based on DNA chip technology that allow surveillance and infection control;
ii) to identify the genomic and expression signatures of particularly virulent strains for future path typing of P. aerations;
iii) to produce crystal structures of active efflux systems of P. aerations involved in mechanism such as multidrug resistance. Efflux pump inhibitors combined with existing antibiotics could increase the susceptibility of P. oreganos to such
iv) to identify new virulence factors using the new host system c. elegant.
Funding SchemeCSC - Cost-sharing contracts