Objective
The goal of the proposed project is the development of novel types of membrane translocation peptides acting as shuttles for a controlled cellular delivery of ant microbial and antiviral drugs, which otherwise do not cross the membrane barrier. Starting point of this proposal are carrier peptides. The outlined experiments shall establish a basic knowledge of the essential requirements for the internalisation of such compounds and lead to model systems in which are effects of systematic variations of known carrier peptide sequences on translocation of drug cargoes across the cell membrane and their biological effects can be explored. In a second step, we will apply our results to develop a new rationale for the selective delivery of ant microbial and antiviral cargoes. Because of they're hydrophobic and polarity the intra- and Tran cellular transport of such therapeutics is particularly challenging. In a third approach, novel antiviral drugs will be developed and new therapeutic concepts will be established. The evaluation of these concepts implicates the application of the translocation carriers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.