Objective The goal of the proposed project is the development of novel types of membrane translocation peptides acting as shuttles for a controlled cellular delivery of ant microbial and antiviral drugs, which otherwise do not cross the membrane barrier. Starting point of this proposal are carrier peptides. The outlined experiments shall establish a basic knowledge of the essential requirements for the internalisation of such compounds and lead to model systems in which are effects of systematic variations of known carrier peptide sequences on translocation of drug cargoes across the cell membrane and their biological effects can be explored. In a second step, we will apply our results to develop a new rationale for the selective delivery of ant microbial and antiviral cargoes. Because of they're hydrophobic and polarity the intra- and Tran cellular transport of such therapeutics is particularly challenging. In a third approach, novel antiviral drugs will be developed and new therapeutic concepts will be established. The evaluation of these concepts implicates the application of the translocation carriers. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator N/A EU contribution No data Address See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Route de Mende 1919 34293 MONTPELLIER See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Avenue Charles Flahault 15 ADR 8 - Languedoc-Rouss 34060 MONTPELLIER See on map Total cost No data JENABIOSCIENCE GMBH, BIOTECHNOLOGIE & GENTECHNIK Germany EU contribution No data Address Loebstedter strasse 78 07749 JENA See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Otto-Hahn-Strasse 11 44027 DORTMUND See on map Total cost No data SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH Switzerland EU contribution No data Address Winterthurerstrasse 190 8057 ZURICH See on map Total cost No data UNIVERSITAT DE BARCELONA Spain EU contribution No data Address 11,c/ Martí i Franquès 1 08028 BARCELONA See on map Total cost No data
