Bluetongue virus (BTV) has a track record of incursion into the EU & causing severe disease & financial losses to our livestock industry. However, the EU has no coherent vaccination policy, which makes BTV incursions difficult or impossible to control. This project will enable an effective policy to be established for the first time by testing the existing live virus vaccines for efficacy & safety, & by providing clear science-based recommendations on their use or otherwise in Europe. The project will also seek to develop & produce inactivated vaccines conferring enhanced protection using state of the art technology with engineered "virus-like particles" & slow release delivery systems. In addition, by sequencing live vaccine strains of BTV & wild strains isolated in the field around Europe, database will be established to enable sourcing of European BTV incursions & early detection of vaccine breakdown thus facilitating targeting of control measures.
Funding SchemeCSC - Cost-sharing contracts
WC1E 7HT London
SW1 7QT London
WC1N 1AX London