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European research programme for improved pertussis strain characterisation and surveillance (EUPERTSTRAIN)

Objective

A European network will conduct coordinated surveillance programmes for peruses disease and collection of B.pertussis isolates, which will be characterized by means of standardized methodology to determine the extent of polymorphism. Strain profiles from historical and prospective sources will be compared to identify trends between vaccination programmes and drift of bacterial populations. Emerging "escape" mutants will be used to challenge protection of different vaccines in a respiratory marine model and will also be subjected to extended genomic analysis by multi-locus sequence typing to identify polymorphism loci. New molecular techniques will be developed to increase throughput of epidemiological typing and reduce costs. The laboratory diagnosis of persistent cough of other aetiology will be approached by means of multi-purpose arrays. In conclusion the results will provide a rational basis for further improvement of peruses cellular vaccines.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL
Address
Nobels Väg 18
171 82 Solna
Sweden

Participants (4)

INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 28
75724 Paris
NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT
Netherlands
Address
9,Antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
13,Kiinamyllynkatu 13
20520 Turku / Abo
STADTISCHE KRANKENHAUSER KREFELD, GEMEINUTZIGE GMBH
Germany
Address
Lutherplatz 40
47805 Krefeld