European research programme for improved pertussis strain characterisation and surveillance (EUPERTSTRAIN)

Objective

A European network will conduct coordinated surveillance programmes for peruses disease and collection of B.pertussis isolates, which will be characterized by means of standardized methodology to determine the extent of polymorphism. Strain profiles from historical and prospective sources will be compared to identify trends between vaccination programmes and drift of bacterial populations. Emerging "escape" mutants will be used to challenge protection of different vaccines in a respiratory marine model and will also be subjected to extended genomic analysis by multi-locus sequence typing to identify polymorphism loci. New molecular techniques will be developed to increase throughput of epidemiological typing and reduce costs. The laboratory diagnosis of persistent cough of other aetiology will be approached by means of multi-purpose arrays. In conclusion the results will provide a rational basis for further improvement of peruses cellular vaccines.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL

Address

Nobels Väg 18
171 82 Solna
Sweden

Participants (4)

INSTITUT PASTEUR

France

Address

Rue Du Docteur Roux 28
75724 Paris

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Netherlands

Address

9,antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven

NATIONAL PUBLIC HEALTH INSTITUTE

Finland

Address

13,kiinamyllynkatu 13
20520 Turku / Abo

STADTISCHE KRANKENHAUSER KREFELD, GEMEINUTZIGE GMBH

Germany

Address

Lutherplatz 40
47805 Krefeld