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Structural and functional genomics of mycobacterium tuberculosis (X-TB)

Objective

As a result of demographic changes, political and social instability, air travel and globalisation, the EU is increasingly threatened by tuberculosis, a chronic respiratory disease that respects no frontiers. The current treatment requires modernisation to improve efficacy and tolerance, and to combat problems of resistance. In this project, structural and functional genomic will be used as tools for drug discovery. Mycobacterium proteins that could serve as novel targets for chemotherapy will be identified, and inhibitors will either be isolated from libraries by using novel screens of natural or (semi) synthetic products or, by using 3D structures as templates for drug design. Other products arising from this proposal include expression libraries, large amounts of mycobacterium proteins, protease and protein linkage maps, and dedicated databases.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 28
75724 Paris
France

Participants (11)

BIRKBECK COLLEGE - UNIVERSITY OF LONDON
United Kingdom
Address
Malet Street University Of London
WC1E 7HX London
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De Luminy, 163 - Case 925
13288 Marseille
HANS KNOELL INSTITUTE FOR NATURAL PRODUCTS RESEARCH
Germany
Address
Beutenbergstrasse 11
07745 Jena
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Obere Zahlbacher Straße 67
55131 Mainz
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Monbijoustrasse 2
10117 Berlin
STATENS SERUM INSTITUT
Denmark
Address
5,Artillerivej 5
2300 Koepenhagen
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Avenue De Luminy 163, Case 925
13288 Marseille
UNIVERSITY OF LAUSANE
Switzerland
Address
Bch (Batiment De Chimie)
1015 Lausanne
UNIVERSITY OF LEICESTER
United Kingdom
Address
The Adrian Building, University Road
LE1 7RH Leicester
UNIVERSITY OF YORK
United Kingdom
Address
Heslington
YO10 5DD York
UNIVERSITÉ DE PROVENCE, AIX-MARSEILLE
France
Address
Avenue De Luminy 163, Case 925
13288 Marseille