Structural and functional genomics of mycobacterium tuberculosis (X-TB)

Objective

As a result of demographic changes, political and social instability, air travel and globalisation, the EU is increasingly threatened by tuberculosis, a chronic respiratory disease that respects no frontiers. The current treatment requires modernisation to improve efficacy and tolerance, and to combat problems of resistance. In this project, structural and functional genomic will be used as tools for drug discovery. Mycobacterium proteins that could serve as novel targets for chemotherapy will be identified, and inhibitors will either be isolated from libraries by using novel screens of natural or (semi) synthetic products or, by using 3D structures as templates for drug design. Other products arising from this proposal include expression libraries, large amounts of mycobacterium proteins, protease and protein linkage maps, and dedicated databases.

Fields of science

• natural sciences › biological sciences › genetics
• medical and health sciences › basic medicine › medicinal chemistry
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• medical and health sciences › health sciences › infectious diseases › RNA viruses › coronaviruses

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT PASTEUR

Address

Rue Du Docteur Roux 28
75724 Paris
France

Participants (11)

BIRKBECK COLLEGE - UNIVERSITY OF LONDON

United Kingdom

Address

Malet Street University Of London
WC1E 7HX London

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Avenue De Luminy, 163 - Case 925
13288 Marseille

HANS KNOELL INSTITUTE FOR NATURAL PRODUCTS RESEARCH

Germany

Address

Beutenbergstrasse 11
07745 Jena

JOHANNES GUTENBERG UNIVERSITAET MAINZ

Germany

Address

Obere Zahlbacher Straße 67
55131 Mainz

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

Address

Monbijoustrasse 2
10117 Berlin

STATENS SERUM INSTITUT

Denmark

Address

5,artillerivej 5
2300 Koepenhagen

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

Address

Avenue De Luminy 163, Case 925
13288 Marseille

UNIVERSITY OF LAUSANE

Switzerland

Address

Bch (Batiment De Chimie)
1015 Lausanne

UNIVERSITY OF LEICESTER

United Kingdom

Address

The Adrian Building, University Road
LE1 7RH Leicester

UNIVERSITY OF YORK

United Kingdom

Address

Heslington
YO10 5DD York

UNIVERSITÉ DE PROVENCE, AIX-MARSEILLE

France

Address

Avenue De Luminy 163, Case 925
13288 Marseille