As a result of demographic changes, political and social instability, air travel and globalisation, the EU is increasingly threatened by tuberculosis, a chronic respiratory disease that respects no frontiers. The current treatment requires modernisation to improve efficacy and tolerance, and to combat problems of resistance. In this project, structural and functional genomic will be used as tools for drug discovery. Mycobacterium proteins that could serve as novel targets for chemotherapy will be identified, and inhibitors will either be isolated from libraries by using novel screens of natural or (semi) synthetic products or, by using 3D structures as templates for drug design. Other products arising from this proposal include expression libraries, large amounts of mycobacterium proteins, protease and protein linkage maps, and dedicated databases.
Funding SchemeCSC - Cost-sharing contracts
WC1E 7HX London
LE1 7RH Leicester
YO10 5DD York