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Preclinical studies of novel heparan mimetics for prevention and treatment of tse (HMS AS ANTI PRION DRUGS)

Objective

Many lines of evidence connect between heparin like polyamines and anti prison activity. All the known anti-prison polyamines inhibit the binding of Prep to heparin sparse, demonstrating a clear connection between the heparin binding activity of Prep and inhibition of prison replication. In an ongoing grant, we are screening a library of novel dextrin based heparin mimetic (Hams) for their in-vitro anti prison activity, and testing the best ones for their in-vivo anti prison activity. We have accomplished a considerable part of the proposed objectives and, most important; have identified a very active compound, which is being tested in-vivo with promising preliminary results. We have also started to delineate there anti prison mechanism. Encourage by these promising results, we now apply for a continuation project in which we hope to
(I) bring the most efficient 'lead' Hams to pre-development stages and
(ii) prepare a pre-clinical filing.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

HADASSAH MEDICAL ORGANIZATION
Address
Hadassah University Hospital
91120 Jerusalem
Israel

Participants (4)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
60-68,Route Du Panorama 18
92265 Fontenay Aux Roses
DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
Address
Nobel House, Smith Square 17
SW1P 36JR London
LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
25,Feodor-lynen-strasse 25
81377 Muenchen
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Address
Crown Street, Derby Building
L69 3BX Liverpool