Objective
Many lines of evidence connect between heparin like polyamines and anti prison activity. All the known anti-prison polyamines inhibit the binding of Prep to heparin sparse, demonstrating a clear connection between the heparin binding activity of Prep and inhibition of prison replication. In an ongoing grant, we are screening a library of novel dextrin based heparin mimetic (Hams) for their in-vitro anti prison activity, and testing the best ones for their in-vivo anti prison activity. We have accomplished a considerable part of the proposed objectives and, most important; have identified a very active compound, which is being tested in-vivo with promising preliminary results. We have also started to delineate there anti prison mechanism. Encourage by these promising results, we now apply for a continuation project in which we hope to
(I) bring the most efficient 'lead' Hams to pre-development stages and
(ii) prepare a pre-clinical filing.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91120 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.