Many lines of evidence connect between heparin like polyamines and anti prison activity. All the known anti-prison polyamines inhibit the binding of Prep to heparin sparse, demonstrating a clear connection between the heparin binding activity of Prep and inhibition of prison replication. In an ongoing grant, we are screening a library of novel dextrin based heparin mimetic (Hams) for their in-vitro anti prison activity, and testing the best ones for their in-vivo anti prison activity. We have accomplished a considerable part of the proposed objectives and, most important; have identified a very active compound, which is being tested in-vivo with promising preliminary results. We have also started to delineate there anti prison mechanism. Encourage by these promising results, we now apply for a continuation project in which we hope to
(I) bring the most efficient 'lead' Hams to pre-development stages and
(ii) prepare a pre-clinical filing.
Funding SchemeCSC - Cost-sharing contracts
92265 Fontenay Aux Roses
SW1P 36JR London
L69 3BX Liverpool