Objective
In view of the increasing threat of Candid infections, particularly to compromised-compromised patients due to non-availability of effective treatments, it is imperative to look for novel drugs with new targets. Such a search appears even more urgent as in Western world the common Candid strains acquire resistance to antiphonals (multidrug resistance, MDR) and thus, severely hamper successful therapy. In this context leading experts in the field have joined their efforts to combat MDR of C.albicans on the following complementary areas:
1) systematic analysis of the functional domains of the transcription regulators and cell surface lipoproteins involved in MDR.
2) Search for new targets of MDR transcription regulators by using micro-array DNA chip technology.
3) Development of a screening system, in a suitable yeast background, for a block in an early regulatory step (including entry of the drug) in the acquired mechanism of MDR. This approach aims at (a) defining novel components of MDR and (b) screening for regulatory inhibitors rather than for new antiphonals, to which fungi are expected to develop resistance in due time.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
53115 Bonn
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.