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Content archived on 2024-05-24

Genetic analysis of the chloroquine drug resistance and accelerated-resistance-to-multiple-drugs phenotype in the human malarial parasite plasmodium falciparum

Objective

Hopes of radical malaria control have been thwarted by the emergence and rapid spread of human malarial parasites that are resistant to every common drug available, including chloroquine, quinine, mefloquine, pyrimethamine, cycloguanil and sulfadoxin. To make matters worse, such multi-drug resistant plasmodium falciparum strains acquire resistances to new antimalarial compounds 1000 times more frequently than do wild-type clones, a phenotype called accelerated resistance to multiple drugs (ARMD), Here we propose a genetic cross to identify the genetic deterministic high level chloroquine drug resistance as well as the accelerated-resistance-to-multiple-drugs phenotype.

Fields of science (EuroSciVoc)

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Topic(s)

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Call for proposal

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Funding Scheme

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Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG
EU contribution
No data
Address
Im Neuenheimer Feld 324
69120 Heidelberg
Germany

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Total cost

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Participants (4)

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