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Genetic analysis of the chloroquine drug resistance and accelerated-resistance-to-multiple-drugs phenotype in the human malarial parasite plasmodium falciparum

Objective

Hopes of radical malaria control have been thwarted by the emergence and rapid spread of human malarial parasites that are resistant to every common drug available, including chloroquine, quinine, mefloquine, pyrimethamine, cycloguanil and sulfadoxin. To make matters worse, such multi-drug resistant plasmodium falciparum strains acquire resistances to new antimalarial compounds 1000 times more frequently than do wild-type clones, a phenotype called accelerated resistance to multiple drugs (ARMD), Here we propose a genetic cross to identify the genetic deterministic high level chloroquine drug resistance as well as the accelerated-resistance-to-multiple-drugs phenotype.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG
Address
Im Neuenheimer Feld 324
69120 Heidelberg
Germany

Participants (4)

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
151,Lange Kleiweg 151
2280 GH Rijswijk Zh
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Boulevard De L'h(pital 91
75643 Paris
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Geert Grooteplein 24
6500 HB Nijmegen
UNIVERSIDAD DEL VALLE
Colombia
Address
Calle 4B # 36-00
Cali