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Biosage coronavirus vector-based vaccine for prevention of foot-and-mouth disease

Objective

A previously developed bio safe transmissible gastroenteritis virus (TGEV) -based vector will be engineered to amplify foot-and-mouth disease cased proteins, to serve as a marked vaccine against FMD. In addition to the bio safety features of the TGEV-based vector, constructions will include exclusively FMDV protease JC and P1-2A (to produce virus-like particles in situate and or a fragment of 3D so that no FMDV can be produced. The TGEV chosen replicates in the enteric and respiratory tracts which are very adequate replication in the enteric and respiratory Antigen expression, immune responses, protection against challenge with virulentFMDV, and possible virus transmission after challenge will be examined using swine, one of the major animal hosts for FMDV. Constructs expressing 20 amino acid sequences of the major antigenic site of FMDV-O and FMDV-C will also be tested in an attempt to broader the immune response.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Universidad Autonoma De Madrid, Cantoblanco
28049 Madrid
Spain

Participants (5)

FORT DODGE VETERINARIA S.A.
Spain
Address
Carretera Camprodon S/n Km 13 Finca "La Riba"
17813 Vall De Bianya
FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
Germany
Address
Boddenblick 5 A
17498 Insel Riems
ID LELYSTAD - INSTITUTE FOR ANIMAL HEALTH AND SCIENCE
Netherlands
Address
Edelhertweg 15
8200 AB Lelystad
INSTITUTE FOR ANIMAL HEALTH
United Kingdom
Address
Ash Road, Nr Woking
GU24 0NF Woking
INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS
Switzerland
Address
Sensemattstrasse 293
3147 Mittelhauesern