Objective
The identification of new targets and the development of new inhibitors are of eminent importance for ant microbial and ant fungal therapy. The project aims at pursuing these goals by addressing partial reactions of protein synthesis on the ribosome. Advanced high-throughput screening assays will be combined with crystal structure determination of inhibitor complexes with potential targets (ribosome's, translation factors) to identify new lead compounds. Inhibitors will be selected from different compound libraries obtained by chemical modification of known antibiotics and new lead compounds, combinatorial chemistry, or isolation from microbial extracts. Inhibition potential and mechanisms will be studied in established bacterial and fungal model systems and in new assay systems derived from pathogenic microorganisms. Emphasis will be on multiresistant organisms causing infections that present particular public health problems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- medical and health sciences health sciences public health
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
58448 WITTEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.