Objective Brucellosis is a zoo nose causing great economical losses and human suffering. In Southern Europe, brucellosis is highly prevalent in small ruminants and, although animal vaccination is essential in eradication, the vaccine available is unsatisfactory. Preliminary evidence suggests that a Rubella lip polysaccharide mutant will have the necessary immunising power and attenuation balance, at the same time, overcome the problems of current vaccines. Thus, the project brings together seven European teams with expertise in Molecular Biology, Immunochemistry, Structural Analysis, Cell Biology and Animal Brucellosis to obtain such mutants and to perform a thorough analysis of the hypothesis, including a genetic, structural and immunochemical characterisation of the mutants, and an analysis of the intracellular behaviour, residual virulence and ability to protect sheep in comparison with vaccine Revel. Fields of science natural sciencesbiological sciencescell biologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesnatural sciencesbiological sciencesmolecular biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSIDAD DE NAVARRA EU contribution No data Address Irunlarrea,1 31008 PAMPLONA Spain See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRO DE INVESTIGACION Y TECNOLOGIA AGROALIMENTARIA DE ARAGON Spain EU contribution No data Address Avda Montanana, 930 50059 ZARAGOZA See on map Total cost No data FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR Belgium EU contribution No data Address Rue de Bruxelles 61 5000 NAMUR / NAMEN See on map Total cost No data INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE France EU contribution No data Address Domaine de l'OrfrasiFre 37380 NOUZILLY See on map Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address F82 - Huddinge University Hospital 141 86 HUDDINGE See on map Total cost No data
