Particular zoonoses such as salmonellosis and influenza are infections frequently transmitted between poultry and man. Extra intestinal pathogenic Escherichia coli (ExPEC) may represent another group of zoonotic pathogens causing sepsis in poultry as well as sepsis and meningitis in man. The zoonotic risk of ExPEC, however, is poorly known. The aim of the project is to analyse the zoonotic risk of human and avian ExPEC strains. A new DNA chip containing human and animal ExPEC patho-genes will be developed, used for epidemiological analysis and for in vitro and in vivo expression profiling. Together with comparison of clonal ExPEC lineages from man and poultry, functional analysis of ExPEC patho-gene products and studies of the molecular basis of host specificity will be performed. This project combines genomics and functional studies to develop new tools to combat one of the most important bacterial human and avian pathogens in Europe.
Funding SchemeCSC - Cost-sharing contracts
69978 Ramat - Aviv