The Hepatitis c virus (HCV) infection affects about 300 million individuals worldwide and at least 5 millions within the EC. Despite recent improvements of therapy, eradication of HCV is not obtained in around 50% of treated patients. This proposal aims to combine a wide functional genomics approach and post-genomic profiling techniques to explore in detail the molecular mechanisms of HCV persistence under interferon therapy. Three workpackages will provide:
1. a comprehensive in vivo analysis of the HCV sequences encoding for proteins (core, E2 and NS5A), implicated in the modulation of cellular signalling, in patients with different profiles of response to therapy;
2. the design of experimental in vivo and in vitro model of HCV protein expression and
3. a detailed analysis of their impact on major transduction networks controlling the cellular response to interferon.
Funding SchemeCSC - Cost-sharing contracts
E1 2AD London