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Analysis of the molecular mechanisms of hepatitis C virus (HCV) resistance to antiviral therapy

Objective

The Hepatitis c virus (HCV) infection affects about 300 million individuals worldwide and at least 5 millions within the EC. Despite recent improvements of therapy, eradication of HCV is not obtained in around 50% of treated patients. This proposal aims to combine a wide functional genomics approach and post-genomic profiling techniques to explore in detail the molecular mechanisms of HCV persistence under interferon therapy. Three workpackages will provide:
1. a comprehensive in vivo analysis of the HCV sequences encoding for proteins (core, E2 and NS5A), implicated in the modulation of cellular signalling, in patients with different profiles of response to therapy;
2. the design of experimental in vivo and in vitro model of HCV protein expression and
3. a detailed analysis of their impact on major transduction networks controlling the cellular response to interferon.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FOUNDATION "ANDREA CESALPINO"
Address
Viale Del Policlinico 151
00161 Roma
Italy

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Du Professeur Calmette 1, Institut De Biologie
59021 Lille
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Du Professeur Calmette 1
59021 Lille
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Vaugirard 156, Faculté De Médecine Necker
75730 Paris
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Mannerheimintie 166
00300 Helsinki
QUEEN MARY AND WESTFIELD COLLEGE - UNIVERSITY OF LONDON
United Kingdom
Address
Turner Street
E1 2AD London
SAARLAND UNIVERSITY
Germany
Address
Kirrberger Str.
66421 Homburg
UNIVERSITÉ DE LILLE II
France
Address
Rue Du Professeur Calmette 1, Institut De Biologie
59021 Lille
UNIVERSITÉ DE PICARDIE - JULES VERNE
France
Address
Rue Du Professeur Calmette 1, Institut De Biologie
59021 Lille