Objective
The Hepatitis c virus (HCV) infection affects about 300 million individuals worldwide and at least 5 millions within the EC. Despite recent improvements of therapy, eradication of HCV is not obtained in around 50% of treated patients. This proposal aims to combine a wide functional genomics approach and post-genomic profiling techniques to explore in detail the molecular mechanisms of HCV persistence under interferon therapy. Three workpackages will provide:
1. a comprehensive in vivo analysis of the HCV sequences encoding for proteins (core, E2 and NS5A), implicated in the modulation of cellular signalling, in patients with different profiles of response to therapy;
2. the design of experimental in vivo and in vitro model of HCV protein expression and
3. a detailed analysis of their impact on major transduction networks controlling the cellular response to interferon.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00161 ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.