Non-melanoma skin cancers (squamous cell and basal cell carcinoma) are the most frequent malignant tumours of man. The etiology of skin cancer is still under debate. Recent reports demonstrated a high prevalence of human-papillomovirus (HPV)-DNA in non-melanoma skin cancers. The etiologic role of some HPV types in the development of cervical cancer is well established. HPV types probably also play a role in head and neck cancers. The identification of HPV in skin cancer may indicate a similar key role in the pathogenesis of skin tumours, which would raise prospects of prevention by vaccination and provide targets for therapeutic options. This proposal is the first unified initiative of nine European institutions in Northern and Southern Europe and one in Australia, each disposing of a long-standing expertise in the field of papillomavirus research and/or epidemiology of skin cancer to study the role of HPV in skin cancer oncogenesis.
Funding SchemeCSC - Cost-sharing contracts
2625 AD Delft
E1 2AT London