Skip to main content

The second phase of a european malaria vaccine development consortium

Objective

The EUROMALVAC2 consortium will develop malaria vaccines inducing protective antibody responses to P.falciparum bloodstage antigens, moving leading vaccine candidates towards GMP-production and clinical trial whilst validating 2nd and 3rd generation candidates in its malaria vaccine R&D 'pipeline '. The major projects within the EUROMALVAC2 work programme involve; a. Optimisation of synthesis of lead candidate malaria vaccines based on merozoite surface protein 1 (MSPl) and the apical merozoite antigen 1 (AMAl). b. Production and testing of more parasitised erythrocyte membrane protein (PfEMP-l) based vaccines. c. Production and testing of new vaccine formulations based on the N-terminal Block 2 sequences of MSP1 and on other, less well characterised merozoite antigens. d. Development of a transmission blocking vaccine based on gametocyte antigen Pfs48/45. e. Strengthening of preclinical and clinical testing facilities.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF EDINBURGH
Address
West Mains Road, Ashworth Laboratories, King's Bu
EH9 3JT Edinburgh
United Kingdom

Participants (11)

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany
Address
Bernhard Nocht Strasse 74
000 Hamburg
COVANCE LABORATORIES LTD
United Kingdom
Address
Otley Road
HG3 1PY Harrogate
FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
Lange Kleiweg 139
2288 GJ Rijswijk Zh
HENOGEN S.A.
Belgium
Address
Rue De La Mariette, 14
7180 Seneffe
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
United Kingdom
Address
Keppel Street
London
MDS PHARMA SERVICES S.A.
France
Address
Les Oncins
69210 St Germain Sur L'arbresle
MRC National Institute for Medical Research
United Kingdom
Address
The Ridgeway Mill Hil
NW7 1AA London
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Geert Grooteplein 10
6500 HB Nijmegen
SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL
Sweden
Address
Nobels Vaeg 18
171 82 Solna
UNIVERSITY OF COPENHAGEN
Denmark
Address
Panum Institute, Building 24.2, Blegdamsvej 3
2200 Koepenhagen