The second phase of a european malaria vaccine development consortium

Objective

The EUROMALVAC2 consortium will develop malaria vaccines inducing protective antibody responses to P.falciparum bloodstage antigens, moving leading vaccine candidates towards GMP-production and clinical trial whilst validating 2nd and 3rd generation candidates in its malaria vaccine R&D 'pipeline '. The major projects within the EUROMALVAC2 work programme involve; a. Optimisation of synthesis of lead candidate malaria vaccines based on merozoite surface protein 1 (MSPl) and the apical merozoite antigen 1 (AMAl). b. Production and testing of more parasitised erythrocyte membrane protein (PfEMP-l) based vaccines. c. Production and testing of new vaccine formulations based on the N-terminal Block 2 sequences of MSP1 and on other, less well characterised merozoite antigens. d. Development of a transmission blocking vaccine based on gametocyte antigen Pfs48/45. e. Strengthening of preclinical and clinical testing facilities.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF EDINBURGH

Address

West Mains Road, Ashworth Laboratories, King's Bu
EH9 3JT Edinburgh
United Kingdom

Participants (11)

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN

Germany

Address

Bernhard Nocht Strasse 74
000 Hamburg

COVANCE LABORATORIES LTD

United Kingdom

Address

Otley Road
HG3 1PY Harrogate

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE

Netherlands

Address

Lange Kleiweg 139
2288 GJ Rijswijk Zh

HENOGEN S.A.

Belgium

Address

Rue De La Mariette, 14
7180 Seneffe

INSTITUT PASTEUR

France

Address

Rue Du Docteur Roux 25
75724 Paris

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

United Kingdom

Address

Keppel Street
London

MDS PHARMA SERVICES S.A.

France

Address

Les Oncins
69210 St Germain Sur L'arbresle

MRC National Institute for Medical Research

United Kingdom

Address

The Ridgeway Mill Hil
NW7 1AA London

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Address

Geert Grooteplein 10
6500 HB Nijmegen

SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL

Sweden

Address

Nobels Vaeg 18
171 82 Solna

UNIVERSITY OF COPENHAGEN

Denmark

Address

Panum Institute, Building 24.2, Blegdamsvej 3
2200 Koepenhagen