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Novel strategies for a safe rotavirus vaccine

Objective

The occurrence of serious side-effects in human infants has led to the withdrawal of the live rotavirus vaccine. Rotavirus diarrhoea is a significant problem and vaccines are urgently needed. Rotavirus-like particles (VLFs) have shown promise as vaccines but not fulfilled their potential. Our objectives will establish if VLPs are an effective and commercially viable alternative. We will construct novel VLPs; monitor the induced immune responses and the mechanisms by which they are induced; design an optimal, practical immunization schedule; assess the efficacy of VLPs to prevent rotavirus diarrhoea; determine the parameters for optimal mass production of VLPs at low cost. Thus, we will have explored the vaccine potential of rotavirus VLPs from the molecular, immunological and commercial viewpoints.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE ROYAL VETERINARY COLLEGE
Address
Hawkshead Lane, North Mymms
AL9 7TA Welham Green,hatfieid
United Kingdom

Participants (4)

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Domaine De Vilvert
78352 Jouy-en-josas
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
Address
Quinta Do Marquos, Av. Da Republica, Estatao Agron
2781-901 Oeiras
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
United Kingdom
Address
Keppel Street
London
SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL
Sweden
Address
Doktorsringen 25
171 82 Solna - 17182