European Commission logo
English English
CORDIS - EU research results
CORDIS
Content archived on 2024-05-15

Novel strategies for a safe rotavirus vaccine

Objective

The occurrence of serious side-effects in human infants has led to the withdrawal of the live rotavirus vaccine. Rotavirus diarrhoea is a significant problem and vaccines are urgently needed. Rotavirus-like particles (VLFs) have shown promise as vaccines but not fulfilled their potential. Our objectives will establish if VLPs are an effective and commercially viable alternative. We will construct novel VLPs; monitor the induced immune responses and the mechanisms by which they are induced; design an optimal, practical immunization schedule; assess the efficacy of VLPs to prevent rotavirus diarrhoea; determine the parameters for optimal mass production of VLPs at low cost. Thus, we will have explored the vaccine potential of rotavirus VLPs from the molecular, immunological and commercial viewpoints.

Call for proposal

Data not available

Coordinator

THE ROYAL VETERINARY COLLEGE
EU contribution
No data
Address
Hawkshead Lane, North Mymms
AL9 7TA WELHAM GREEN,HATFIEID
United Kingdom

See on map

Total cost
No data

Participants (4)