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Optimizing dna based vaccination against fmdv in sheep and pigs

Objective

The final objective of this proposal is to develop optimised strategies of DNA vaccination to foot-and-mouth disease (FMD) in sheep and pigs, for potential use as vaccines including those for " emergency" depending on EU policy of FMDV eradication programmes. One of the major advantages of DNA vaccination over current inactivated vaccines is the avoidance of the costly manipulation of infectious virus in high containment facilities and the risk of infection in the animal due to insufficient inactivation. The ways by which the FMDV DNA vaccine strategy will be optimised will include a comparison of the immunogenicity in sheep and pigs of different FMDV antigens, of a new generation of plasmids, of promising adjuvants for DNA vaccines, of parenteral versus nasal routes of administration and of prime-boost regimens. The protocols giving the best immune responses will be used to evaluate protection to FMDV challenge in sheep and pigs.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
Domaine De Vilvert
78352 Jouy-en-josas
France

Participants (3)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
France
Address

22440 Ploufragan
INSTITUTE FOR ANIMAL HEALTH
United Kingdom
Address
Ash Road, Nr Woking
GU24 0NF Woking
INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA
Spain
Address
Carreteria De Algete A El Casar Km 8.1 S/n
28130 Valdeolmos - Madrid