The final objective of this proposal is to develop optimised strategies of DNA vaccination to foot-and-mouth disease (FMD) in sheep and pigs, for potential use as vaccines including those for " emergency" depending on EU policy of FMDV eradication programmes. One of the major advantages of DNA vaccination over current inactivated vaccines is the avoidance of the costly manipulation of infectious virus in high containment facilities and the risk of infection in the animal due to insufficient inactivation. The ways by which the FMDV DNA vaccine strategy will be optimised will include a comparison of the immunogenicity in sheep and pigs of different FMDV antigens, of a new generation of plasmids, of promising adjuvants for DNA vaccines, of parenteral versus nasal routes of administration and of prime-boost regimens. The protocols giving the best immune responses will be used to evaluate protection to FMDV challenge in sheep and pigs.
Funding SchemeCSC - Cost-sharing contracts
GU24 0NF Woking
28130 Valdeolmos - Madrid