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Unraveling hcv pathogenicity for the preclinical development of new therapeutic strategies (HEPCVAX)

Objective

The overall objectives of the HepCVax cluster is to identify viral and host mechanisms which are involved in
(I) viral replication and particle formation,
(ii) pathogen city and viral persistence and, based on the knowledge of virus properties as well as virus-host interactions and pathogenesis,
(iii) to identify innovative antiviral and immunotherapeutic strategies capable of inducing a broad and sustained HCV specific cellular-mediated immune responses. All information emerging from the understanding of the HCV genome will be integrated in the first ever-European sequence database dedicated to Hepatitis C virus. The cluster will be subdivided in three component Networks. Whereas HepCVax-PARTIC will concentrate on the molecular and intracellular level of the virus-host interactions through the identification of factors involved in HCV-particles formation, HepCVax.IMPA TH will focus on the interaction between HCV and different arms of the innate and adaptive immune response. HepCVax-PRECLIN will exploit the expected discoveries made by Networks 1 and 2 to develop and test new immunotherapeutic strategies in vitro and in small animal models.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
Albinusdreef 2
2300 RC Leiden
Netherlands

Participants (15)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
Address
Hugstetterstr. 55
79106 Freiburg (In Breisgau)
BIOMERIEUX SA
France
Address
Cervi - 21, Av. Tony Garnier
69365 Lyon
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Du Professeur Calmette 1
59021 Lille
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Allte D'italie 46
69364 Lyon
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
7,Passage Du Vercors 7
69367 Lyon
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue Koeberle 3 Adr 16 - Alsace
67000 Strasbourg
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
46, Allee D'italie
69634 Venissieux
LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
Marchioninistr. 15
81377 Muenchen
PEVION BIOTECH AG
Switzerland
Address
Rehhagstrasse 79
3018 Bern
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
John Radcliffe Hospital - Oxfordshire 5802
OX3 9DU Oxford/headington
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Piazza Umberto I Palazzo Ateneo 1
70121 Bari
UNIVERSITAETSKLINIKUM HEIDELBERG
Germany
Address
Otto-meyerhof-zentrum, Im Neuenheimer Feld 324
69120 Heidelberg
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
Passage Du Vercors 7
69367 Lyon
UNIVERSITE DE PARIS V 'RENÉ DESCARTES'
France
Address
156,Rue De Vaugirard 156, Chu Necker
75730 Paris
UNIVERSITY OF BERNE
Switzerland
Address
49,Murtenstrasse 35
3010 Bern