European vaccine effort against HIV/AIDS - III

Objective

A vaccine against HIV-1/AIDS is urgently needed to slow down the current epidemic in both Africa and Asia. The predominant subtype of HIV-1 causing the AIDS epidemic in Africa and Asia is subtype C. Clinical lots of priming agents - Gemlike Forest virus (SFV) and naked DNA -, as well as a boosting agent - the attenuated poxvirus strain NYV AC -, are prepared; all vaccine components are derived from HIV-1 subtype C and include the gag, poll, net and envy genes. The objective of the Euro Vac-III demonstration project is to identify the best priming agent, DNA vs. SFV, that allows for reduction of the NYVAC dose without significant loss of immunogenicity. This demonstration project aims for the establishment of the most immunogenic vaccine that is suitable for mass vaccination and forms the last step towards moving into phase IIb and III efficacy trials.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

DEM - Demonstration contracts

Coordinator

KAROLINSKA INSTITUTE

Address

13,Nobels Väg 16
171 77 Stockholm
Sweden

Participants (8)

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

Address

Meibergdreef 15
1105AZ Amsterdam

AVENTIS PASTEUR SA

France

Address

1541,Avenue Marcel Mérieux 1541
69280 Marcy-l'etoile

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Campus De La Universidad Autonoma De Madrid
28049 Madrid

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

Address

Du Cane Road
W12 0NN London

MEDICAL RESEARCH COUNCIL

United Kingdom

Address

Euston Road, 222
W1N 4AL London

MUNICIPAL HEALTH SERVICE

Netherlands

Address

Nieuwe Achtergracht 100
1018 WT Amsterdam

UNIVERSITAET REGENSBURG

Germany

Address

11,Frans-joseph-strauss-allee 11
93053 Regensburg

UNIVERSITY OF LAUSANE

Switzerland

Address

Avenue De Beaumont 29 Hopital Beaumont
1011 Lausanne