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The occurrence, detection and treatment of adenovirus infection in patients undergoing allogeneic stem cell transplantation

Objective

Future progress in hemopoietic stem cell transplantation is hampered by disseminated adenoviral (AdV) infection, which is estimated to kill 175 transplant patients in EU yearly. Current virological tests are poor either for predicting those patients who will develop life threatening AdV disease or evaluating the efficacy of antiviral drugs. We therefore propose to perform rapid, sensitive quantitation of plasma adenoviral DNA load in a multi-centre prospective study using Real -Time Quantitative PCR (RQ-PCR) for disease monitoring, prognostication and monitoring of responses to antiviral drugs, in conjunction with pharmacokinetic/dynamic studies and in vitro AdV sensitivity. AdV-specific T-cell reactivity and neutralizing antibodies will be measured in all patients to explore the feasibility of immunotherapy. Based on the data a protocol for the management of AdV infections in immunocompromised hosts will be delivered to the community.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
Albinusdreef 2
2333 AL Leiden
Netherlands

Participants (4)

INSTITUTE OF HAEMATOLOGY AND BLOOD TRANSFUSION
Czechia
Address
U. Nemocnice 1
128 20 Praha 2
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
Hopital Debrousse, Rue Soeur Bouvier 29
69322 Lyon
UNIVERSITY OF BRISTOL
United Kingdom
Address
University Walk
BS8 1TD Bristol, Clifton
UTRECHT UNIVERSITY
Netherlands
Address
Lundlaan 6
3508 AB Utrecht