Objective
Future progress in hemopoietic stem cell transplantation is hampered by disseminated adenoviral (AdV) infection, which is estimated to kill 175 transplant patients in EU yearly. Current virological tests are poor either for predicting those patients who will develop life threatening AdV disease or evaluating the efficacy of antiviral drugs. We therefore propose to perform rapid, sensitive quantitation of plasma adenoviral DNA load in a multi-centre prospective study using Real -Time Quantitative PCR (RQ-PCR) for disease monitoring, prognostication and monitoring of responses to antiviral drugs, in conjunction with pharmacokinetic/dynamic studies and in vitro AdV sensitivity. AdV-specific T-cell reactivity and neutralizing antibodies will be measured in all patients to explore the feasibility of immunotherapy. Based on the data a protocol for the management of AdV infections in immunocompromised hosts will be delivered to the community.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences clinical medicine transplantation
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2333 AL LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.