Virological characterisation of primary hiv infection in the concerted action on seroconversion to aids and death in europe (CASCADE VIROLOGY)

Objective

This project will combine data from European cohorts of persons with known dates of HIV seroconversion (seroconverters) to assess to what extent transmission with drug resistant HIV impacts on clinical outcome. The individual cohorts have been specifically set up as HIV natural history cohorts and study subjects are followed-up life-long from their initial contact with HIV. Although transmitted drug resistance has been documented, but may be under-estimated if data are not derived from seroconverters, its clinical importance has not been established. In studies of persons with known dates of seroconversion, the numbers included are often small and it is very difficult to draw conclusions, on whether a blunted immunology and virology response to therapy is more likely in someone newly infected with drug resistant virus than someone who is not.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CON - Coordination of research actions

Coordinator

MEDICAL RESEARCH COUNCIL

Address

Euston Road, 222
W1N 4AL London
United Kingdom

Participants (13)

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

Address

Meibergdreef 15
1105AZ Amsterdam

BIRMINGHAM HEARTLANDS & SOLIHULL NHS TRUST (TEACHING)

United Kingdom

Address

Bordesley Green East
B9 5SS Birmingham

CENTRE HOSPITALIER ET UNIVERSITAIRE DE BORDEAUX

France

Address

Place Amelie Raba Leon
33076 Bordeaux

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

146,Rue Léo Saignat 146, Université Victor Segalen
33076 Bordeaux

INSTITUTE OF HEALTH CARLOS III

Spain

Address

Calle Sinesio Delgardo 6
28029 Madrid

ISTITUTO SUPERIORE DI SANITA

Italy

Address

Viale Regina Elena 299
00161 Roma

MUNICIPAL HEALTH SERVICE

Netherlands

Address

Nieuwe Achtergracht 100
1018 WT Amsterdam

ODENSE UNIVERSITY HOSPITAL

Denmark

Address

Sdr. Boulevard
5000 Odense

STATENS SERUM INSTITUT

Denmark

Address

Artillerivej 5
2300 Koepenhagen

THE UNIVERSITY OF MILANO

Italy

Address

L. Sacco Hospital, Via Gb Grassi 74
20157 Milano

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Spain

Address

Ctra Valencia Alicante Km 87 Campus San Juan
03550 San Juan De Alicante

UNIVERSITY COLLEGE LONDON

United Kingdom

Address

Cleveland Street, 46 - Windeyer Building
W1T 4JF London

UNIVERSITY OF TARTU

Estonia

Address

Ravila 19
50411 Tartu