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Virological characterisation of primary hiv infection in the concerted action on seroconversion to aids and death in europe (CASCADE VIROLOGY)

Objective

This project will combine data from European cohorts of persons with known dates of HIV seroconversion (seroconverters) to assess to what extent transmission with drug resistant HIV impacts on clinical outcome. The individual cohorts have been specifically set up as HIV natural history cohorts and study subjects are followed-up life-long from their initial contact with HIV. Although transmitted drug resistance has been documented, but may be under-estimated if data are not derived from seroconverters, its clinical importance has not been established. In studies of persons with known dates of seroconversion, the numbers included are often small and it is very difficult to draw conclusions, on whether a blunted immunology and virology response to therapy is more likely in someone newly infected with drug resistant virus than someone who is not.

Funding Scheme

CON - Coordination of research actions

Coordinator

MEDICAL RESEARCH COUNCIL
Address
Euston Road, 222
W1N 4AL London
United Kingdom

Participants (13)

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Address
Meibergdreef 15
1105AZ Amsterdam
BIRMINGHAM HEARTLANDS & SOLIHULL NHS TRUST (TEACHING)
United Kingdom
Address
Bordesley Green East
B9 5SS Birmingham
CENTRE HOSPITALIER ET UNIVERSITAIRE DE BORDEAUX
France
Address
Place Amelie Raba Leon
33076 Bordeaux
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
146,Rue Léo Saignat 146, Université Victor Segalen
33076 Bordeaux
INSTITUTE OF HEALTH CARLOS III
Spain
Address
Calle Sinesio Delgardo 6
28029 Madrid
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
MUNICIPAL HEALTH SERVICE
Netherlands
Address
Nieuwe Achtergracht 100
1018 WT Amsterdam
ODENSE UNIVERSITY HOSPITAL
Denmark
Address
Sdr. Boulevard
5000 Odense
STATENS SERUM INSTITUT
Denmark
Address
Artillerivej 5
2300 Koepenhagen
THE UNIVERSITY OF MILANO
Italy
Address
L. Sacco Hospital, Via Gb Grassi 74
20157 Milano
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Address
Ctra Valencia Alicante Km 87 Campus San Juan
03550 San Juan De Alicante
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Cleveland Street, 46 - Windeyer Building
W1T 4JF London
UNIVERSITY OF TARTU
Estonia
Address
Ravila 19
50411 Tartu