Objective
Tees are invariably fatal and are still incurable. Recent reports have shown that anti-Prepuce antibodies reduce Preps in infected-infected cells. Based on this data, we have infused anti-Prep antibody Fib fragments intracerebroventricularly in FVB mice with experimental scrape and demonstrated a delay in the clinical signs. The aims of this project are:
(i) to confirm these encouraging results in mice with experimental scrape or BSE,
(ii) to optimise immunotherapy protocols (intracerebroventricular and intraperitoneal),
(iii) to combine this immunotherapy with emerging chemotherapeutic agents including the chlorpromazine/aquamarine regimen, and
(iv) to rationally improve the anti-Prep antibodies, by creating chimerical constructs with targeted transcytosis through the blood/brain endothelium. These studies will culminate in phase I clinical trials in human niche and CJD patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1066 CX AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.