Objective
Medically-important polyketide antibiotics produced by streptomycetes often contain deoxysugar residues essential for their function. Altering these sugars would be a powerful route to new antibiotics. Increasing microbial resistance makes this an urgent need. This proposal is to study production of novel glycosylated polyketides, using knowledge of the biosynthetic pathways to deoxyhexoses (6-DOH). The word includes:
1) complementation of mutants in deoxysugar pathways to generate hybrid glycosylated compounds
2) Production of hybrid antibiotics by adding aglycones to cells containing gene sets specifying synthesis of a deoxysugar, together with cloned glycosyltransferases (GTases)
3) use of enzymes for synthesis of 6-DOH in production of activated substrates for Gtases
4) use of purified GTases with activated deoxysugars, for biotransformation of aglycones 5) DNA shuffling of GTases genes and selection in vivo for bioactivity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Coordinator
CB2 1GA CAMBRIDGE
United Kingdom
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