Objective
Gene transfer by liposome-encapsulated DNA has several important advantages over other methods of gene transfer.
1) The method is safe.
2) There is no limit to the encapsulated expression vector size or conformation.
3) The liposomes are non-toxic and non-immunogenic and therefore can be injected repeatedly. Previous studies done by some of the participants indicated that liposomes-encapsulated DNA can mediate gene transfer into internal organs - mainly the liver and lungs, following intravenous injection, and gene transfer into the liver during operation procedure therapy applications will be developed toward clinical practice: A)Gene therapy of liver and lung cancer by IL-2 and interferon gamma-gene transfer (to induce immune reaction against the cancer cells) and combination of chemotherapy and cytokine gene transfer. B)Induction of tolerance to liver allograft by liposome mediated gene transfer of CTLA4-lg (which blocks the activation of the T lymphocytes and therefore the graft rejection into the transplanted liver following the transplantation). C)DNA vaccination against hepatitis C virus by liposome-mediated gene transfer of viral genes into the liver. In each of these applications, local and transient expression of the transferred gene is an advantage since biological activity can be obtained without serious side effects that high level of systemic expression might cause.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation phytoremediation
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences health sciences infectious diseases
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50923 Köln
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.