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Cliniporator: a new adaptative generator for dna electrotransfer in vivo for gene therapy

Objective

The objective is to improve the knowledge about nutrient utilization during and after periods of malnutrition. The focus is put on optimal strategies for human nutrition, but the investigations will be performed with animals as models. It will include comparative measurements of nutrient metabolism during malnutrition and measurements of food intake regulation and nutrient utilization during recovery periods. The results will be used for establishment of comparative animal and human models of growth and reproduction and to elucidate effect of metabolic programming on substrate utilization. The emphasis will be put on combined methods of indirect calorimetry, nutrient balances, stable isotope techniques and gene expression analyses in order to provide quantitative data at the whole body level as well as at tissue level. Animal models will be implemented to nutrient requirements of humans during recovery.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
39,Rue Camille Desmoulins 39
94805 Villejuif
France

Participants (7)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
205,Route De Narbonne 205
31077 Toulouse
HERLEV UNIVERSITET HOSPITAL
Denmark
Address
75, Herlev Ringvej
2730 Herlev
IGEA
Italy
Address
Viale Della Chimica , 21
41012 Carpi
LUND UNIVERSITY
Sweden
Address
Paradisgatan 2
221 00 Lund
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
Place De L'universite 1
Louvain-la-neuve
UNIVERSITY OF BIELEFELD
Germany
Address
Universitätsstraße 25
33501 Bielefeld
UNIVERSITY OF LJUBLJANA
Slovenia
Address
Kongresni Trg 12
1000 Ljubljana