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Biomechanical interactions in tissue engineering and surgical repair

Objective

The aim of this project is to develop a protein-based subunit vaccine against diseases caused by S. pneumonia by preventing its colonisation of the human nasopharinx. Target antigens will be identified among surface proteins which act as adhesins. The first years will be devoted to the discovery of new adhesins and to determine the degree of their allelic/antigenic variation. The role of putative adhesins, selected via genomics and bioinformatics, will be tested using single and combined knock-out mutants in adhesion assays and in a mouse pharyngeal colonization model. Mouse immunization studies will be performed using purified recombinant proteins and the live vaccine vector S.gordonii. Mucosal delivery will be by the nasal route and by colonization of the upper respiratory tract with the live vector. Protection from colonization and from invasive disease will be evaluated, together with the local and systemic immune responses.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF KEELE
Address
Keele University
ST5 5BG Staffordshire
United Kingdom

Participants (8)

BIOCOMPOSITES LIMITED
United Kingdom
Address
Etruscan Street Etruria
ST1 5PQQ Stoke-on-trent
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
146,Rue Léo Saignat 146 Adr9 - Aquitaine, Université
33076 Bordeaux
LINKOEPING UNIVERSITY
Sweden
Address
Hus Origo Campus Valla
581 83 Linkoeping
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
Trinity College
2 Dublin
UNIVERSITY OF GENOVA
Italy
Address
Via Balbi 5
16126 Genova
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
Birkbeck College, University of London
United Kingdom
Address
Malet Street, Bloomsbury
WC1E 7HX London
VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam