Skip to main content

Technology for the production of health related substances by marine sponges

Objective

Interesting new compounds have been isolated from marine sponges: e.g. cytotoxic compounds that may be used as anti-cancer drugs, antibiotics, anti-viral agents and compounds with anti-inflammatory and cardiovascular properties. Biotechnological production under well defined conditions of sponge biomass is a necessary step towards commercialization of these potentially interesting products. So far, no primary-cell suspension cultures showed growth. Sponge cells need cell-cell contact to proliferate. In order to obtain axenic sponge tissue cultures, sponges can be dissociated, cleaned from other organisms than the sponge cells and reaggregated. Primary cell cultures can be reaggregated to strong spherical aggregates, primmorphs. The goal is to develop a process for in vitro cultivation of marine sponges for the production of biological active compounds. Sponges will be grown as primmorphs in bioreactors. Optimisation of the growth of and isolation of bioactive components from these primmorphs is the main objective of the project. A process design (including the market analysis) will be made.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

WAGENINGEN UNIVERSITY
Address
Costerweg 50
Wageningen
Netherlands

Participants (4)

JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
6,Duesbergweg 6
55099 Mainz
KLINIPHARM DIA MED VERTRIEBS GMBH
Germany
Address
Hochstrasse 2
60313 Frankfurt Am-main
NATIONAL INSTITUTE OF CHEMICAL PHYSICS AND BIOPHYSICS
Estonia
Address
23,Akademia Tee 23
12618 Tallinn
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Piazzale Aldo Moro 7
00185 Roma