Objective
The research aims to find novel therapeutic substances.
This will be achieved by:
i) screening of bacteria, preferably actinomycetes and cyanobacteria with modern fingerprinting techniques and by;
ii) combinatorial biosynthesis.
The later approach includes the creation of expression system for cyanobacteria genes. The compounds obtained from wild type bacteria and those derived from genetically engineered strains are screened through antimicrobial, antitumour and receptor based systems. Biopharmaceutical evaluation of the hits that will be found in the project lead to optimisation of the promising target molecule in the early phase of drug development process. Seven European groups, four academic and three SMEs form the multidisciplinary team to make the project.
Cyanomyces-project as an EC-funded project has been finished, however the project is continued on its own. The screening techniques have been established. Altogether 314 actinomycetes and 273 cyanobacteria were screened and detailed primary analysis of the data of different approaches, DNA-fingerprinting, chemical characterization (HPLC and MALDI-TOF-MS) and bioactivity assays was done. Easily isolated natural compounds, mainly those from actinomycetes have been purified and were structurally elucidated including three new products. However, after evaluation of the screening data we have promising hits, which will be isolated in the future. Biopharmaceutical studies with the model molecule, a known compound, were started. Genes identified are currently in heterologous expression studies in Streptomyces hosts. So far two new compounds have been identified from GMOs. Expression of cyanobacterial genes in a Streptomyces host was successful. This was the first time when the expression of cyanobacteria-derived gene was reported.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences microbiology bacteriology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
KAARINA
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.