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Engineering integrated biocatalysts for the production of chiral epoxides and other pharmaceutical intermediates

Objective

A group of convenient choral intermediates for the production of pharmaceuticals are epoxies and 2-substituted alcohols. Environmentally safe preparation of these compounds is preferably done via biocatalysts. However, the required enzymes are often not available. Therefore, we will develop new biocatalysts and explore new bio catalytic strategies for the preparation of these choral compounds. For this, we will use innovative methods: screening of genomic databases for homologues of known useful enzymes; directed evolution with high-throughput screening for improved enantioselectivity; and genetic construction of biocatalysts in which different conversion steps are integrated. We aim at developing new synthetic routes exploiting novel concepts of enantiocomplementarity and enantioconvergence, thus minimising the cost of resources and the production of waste.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF GRONINGEN
Address
Nijenborgh 4
9747 AG Groningen
Netherlands

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De Luminy 163, Case 901
13288 Marseille
FLUKA PRODUCTION GMBH
Switzerland
Address
Industriestrasse 25
9470 Haag
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address

SW7 2AY London
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Obere Zahlbacher Straße 67
55131 Mainz
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Kaiser-wilhelm-platz 1
45470 Muelheim An Der Ruhr
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Avenue De Luminy 163
13288 Marseille