A group of convenient choral intermediates for the production of pharmaceuticals are epoxies and 2-substituted alcohols. Environmentally safe preparation of these compounds is preferably done via biocatalysts. However, the required enzymes are often not available. Therefore, we will develop new biocatalysts and explore new bio catalytic strategies for the preparation of these choral compounds. For this, we will use innovative methods: screening of genomic databases for homologues of known useful enzymes; directed evolution with high-throughput screening for improved enantioselectivity; and genetic construction of biocatalysts in which different conversion steps are integrated. We aim at developing new synthetic routes exploiting novel concepts of enantiocomplementarity and enantioconvergence, thus minimising the cost of resources and the production of waste.
Funding SchemeCSC - Cost-sharing contracts
SW7 2AY London
45470 Muelheim An Der Ruhr