Amino acids and vitamins play an essential role in economic and ecologically sociable animal nutrition in stock farming. Corynebacterium glutamicum has been chosen as a bacterial cell factory to study the biological production of the amino acid L-valise and the vitamin D-antithetic acid by a rational approach using genome research for metabolic engineering. This approach is based on a whole-genome analysis with the principle idea to use genome-wide data and innovative technologies such as DNA chip technology, transcriptomics and polemics. Genetic and metabolic targets will be identified in multi-disciplinary approaches to develop new generations of production strains. Small-scale simulation studies will provide a sound basis for the subsequent industrial scale-up.
Funding SchemeCSC - Cost-sharing contracts
33788 Kuensebeck I. W.
142 20 Praha 4
91405 Gometz La Ville
B15 2TT Birmingham