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Construction of corynebacterium glutamicum strains producing either l-valine or d-pantothenic acid - a rational approach using genome research

Objective

Amino acids and vitamins play an essential role in economic and ecologically sociable animal nutrition in stock farming. Corynebacterium glutamicum has been chosen as a bacterial cell factory to study the biological production of the amino acid L-valise and the vitamin D-antithetic acid by a rational approach using genome research for metabolic engineering. This approach is based on a whole-genome analysis with the principle idea to use genome-wide data and innovative technologies such as DNA chip technology, transcriptomics and polemics. Genetic and metabolic targets will be identified in multi-disciplinary approaches to develop new generations of production strains. Small-scale simulation studies will provide a sound basis for the subsequent industrial scale-up.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BIELEFELD
Address
Universitaetstrasse 25
33501 Bielefeld
Germany

Participants (12)

ASOCIACION DE INVESTIGACION INSTITUTO DE BIOTECNOLOGIA DE LEON
Spain
Address
Avenida Del Real 1 Parque Cientifico De Leon
24006 Leon
DEGUSSA-HUELS AKTIENGESELLSCHAFT
Germany
Address
Kantstraat 2
33788 Kuensebeck I. W.
FORSCHUNGSZENTRUM JUELICH GMBH
Germany
Address
Leo-brandt-strasse
52425 Juelich
INSTITUT FUER INNOVATIONSTRANSFER AN DER UNIVERSITAET BIELEFELD GMBH
Germany
Address
Universitaetsstrasse 25
33615 Bielefeld
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
France
Address
Centre De Bioingénierie Gilbert Durand Complexe S
31077 Toulouse
INSTITUT NATIONAL POLYTECHNIQUE DE LORRAINE
France
Address
Avenue De La Forêt De Haye 2
54505 Vandoeuvre-les-nancy
INSTITUTE OF MICROBIOLOGY - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
142 20 Praha 4
INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY UNIVERSITY OF LATVIA
Latvia
Address
Kronvalda Boulevard 4
1586 Riga
UNIVERSITAET KOELN
Germany
Address
47,Zülpicherstrasse 47
50674 Koeln
UNIVERSITE DE PARIS-SUD XI
France
Address
Rue Georges Clemenceau 15, Bftiment 400
91405 Gometz La Ville
UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
B15 2TT Birmingham
UNIVERSITY OF ULM
Germany
Address
Albert-einstein-allee 11
89081 Ulm