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Towards new antibiotics

Objective

This project will produce Cell Factories (CAS) for the clean synthesis of antibiotics (presently produced via costly and environmentally unfriendly procedures), production of templates for modification into antibiotics/beta-lactamase inhibitors and which will make possible the commercial production of broad-spectrum beta-lactamase inhibitors. The CAS will utilise modified versions of natural enzymes involved in beta-lactic biosynthesis. The work will involve implementation of five Work Packages forming an integrated program with detailed structural, bioinorganic, engineering and fermentation studies on the relevant enzymes. The project will also produce a structural database for ferrous dependent oxygenases, define rules for engineering their selectivity and develop new methodology for crystallography and mutant screening.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
South Parks Road
OX1 3QT Oxford
United Kingdom

Participants (4)

AMURA LIMITED
United Kingdom
Address
St John's Innovation Centre, Cowley Road
CB4 0WS Cambridge
THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES
Sweden
Address
10,Arrheniusplan 2C
750 07 Uppsala
UNIVERSITE DE LIEGE*ULG
Belgium
Address
Place Du 20 Aout 7
4000 Liege
UPPSALA UNIVERSITY
Sweden
Address
Sankt Olofsgatan 10 B
75105 Uppsala