Towards new antibiotics

Objective

This project will produce Cell Factories (CAS) for the clean synthesis of antibiotics (presently produced via costly and environmentally unfriendly procedures), production of templates for modification into antibiotics/beta-lactamase inhibitors and which will make possible the commercial production of broad-spectrum beta-lactamase inhibitors. The CAS will utilise modified versions of natural enzymes involved in beta-lactic biosynthesis. The work will involve implementation of five Work Packages forming an integrated program with detailed structural, bioinorganic, engineering and fermentation studies on the relevant enzymes. The project will also produce a structural database for ferrous dependent oxygenases, define rules for engineering their selectivity and develop new methodology for crystallography and mutant screening.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

South Parks Road
OX1 3QT Oxford
United Kingdom

Participants (4)

AMURA LIMITED

United Kingdom

Address

St John's Innovation Centre, Cowley Road
CB4 0WS Cambridge

THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES

Sweden

Address

10,Arrheniusplan 2C
750 07 Uppsala

UNIVERSITE DE LIEGE*ULG

Belgium

Address

Place Du 20 Aout 7
4000 Liege

UPPSALA UNIVERSITY

Sweden

Address

Sankt Olofsgatan 10 B
75105 Uppsala