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The dt40 cell line as a genetic model and a substitute for animal research

Objective

The proposal will establish the DT40 cell line as a powerful and cost efficentalternative to animal research. DT40 is already popular for genetic research in cell biology, but further progress depends on better co-ordination among laboratories and the establishment of generic resources. Close collaborations will be set up between research laboratories and an emerging biotech company to generate useful DT40 variant cell lines, read-out assays and a comprehensive expression sequence tag (EST) database. This will allow analysing the function of thousands of genes by disruption in cell culture thereby substantially decreasing the need for animal Tran genesis and the breeding of knockout mice. The new knowledge and resources will be commercially exploited for protein expression and drug discovery.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

HEINRICH-PETTE-INSTITUT FUER EXPERIMENTELLE VIROLOGIE UND IMMUNOLOGIE AN DER UNIVERSITAET HAMBURG
Address
Martinistraße 52
20251 Hamburg
Germany

Participants (6)

CISTRONICS CELL TECHNOLOGY GMBH
Switzerland
Address
Einsteinstrasse 1-5
8093 Zurich
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Neuherberg
INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES
Poland
Address
36,Pawinskiego 5A
02-106 Warszawa
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Institute Of Medical Sciences, Foresthill
AB25 2ZD Aberdeen
UNIVERSITY OF NOTTINGHAM
United Kingdom
Address
University Park
NG7 2RD Nottingham
UNIVERSITY OF TURKU
Finland
Address
Kiinamyllynkatu 13
20520 Turku / Abo