Objective
The candidate will extend her skills in handling and manipulating retroviral vectors to the more complexes subgroup of lent viruses, which prove to become a promising tool for gene therapy applications. She will receive training in the identification and culture of haematopoietic stem cells as also in analysis of these cells for their tot potency (in vitro essays and repopulation of NOD/SCID mouse) by FACS analysis. She will gain detailed knowledge on genetic manipulation of envelope lipoprotein and virus pseudotyping. A long-term goal of the host lab is to find solutions to allow in vivo gene delivery via the inoculation of integrative vectors derived from retroviruses. The host has the expertise to engineer upgraded retroviral vectors derived from marine leukaemia viruses, and found solutions to enhance their bio safety, capacity to specifically recognize target cells, improve vector titters and allow stability in human serum. More recently, the host lab developed lent viral vectors derived from primate lent viruses, which allow transudation of some non-proliferating cells. Here we are looking to make a further step toward the generation of vectors suitable for in vivo gene delivery by overcoming the problems that still limit gene transfer to some important gene therapy targets. It is expected that numerous applications in gene therapy will be possible after....
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences microbiology virology
- humanities languages and literature literature studies literary genres essays
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology leukemia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69364 LYON
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.