Objective Developing therapeutic strategies for Tees is of great public concern, especially since the advent of variant CJD. We will examine, in a comprehensive and integrate-ed manner, novel candidate drugs targeting different key events in infected pathogen-sis. We will identify compounds that disrupt the structure of prisons (reducing infectivity), inhibit Preps production &/or prevent Induced-induced neurotoxicity. The compounds will then be tested for their ability to inhibit infected replication in lymphoid tissues, block neuroinvasion, inhibit establishment of infection in the CNS &/or retard pathological changes in the brain that lead to clinical disease. These objectives will be attained through combined high throughput in vitro screening systems & defined animal models. Insights into mechanisms of infected disease pathogenesis will be obtained. The outcome will be named compounds that could be used to treat TSE disease in man or inactivate infectivity in biomedical products. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF GLASGOW Address Bearsden G61 1QH Glasgow United Kingdom See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution € 0,00 Address Rue de la federation 31-33 75015 Paris See on map ISTITUTO NAZIONALE NEUROLOGICO 'CARLO BESTA' Italy EU contribution € 0,00 Address Via celoria 11 20133 Milano See on map MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italy EU contribution € 0,00 Address Via eritrea 62 20157 Milano See on map PEPSCAN SYSTEMS B.V. Netherlands EU contribution € 0,00 Address Edelhertweg 15 8203 AB Lelystad See on map VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS Netherlands EU contribution € 0,00 Address De boelelaan 1105 1081 HV Amsterdam See on map
