Objective
This proposal concerns the evaluation of the enzyme deoxyuridine troposphere nucleotidohydrolase as a drug target against bacterial, protozoan and mycobacterium infections. The diseases of particular interest are malaria, leishmaniasis, African trypanosomiasis, Changes' disease, bacterial infections and mycobacterium infections such as tuberculosis. This enzyme may also have application as an anticancer target. The enzyme is essential for the viability of the organism and represents a novel drug target. The following is planned: cloning and over expression of the enzyme from key pathogens; crystallisation and x-ray crystallography of the enzymes; drug design using molecular modelling; screening of a large database of compounds to provide novel leads; synthesis of potential inhibitors; screening of compounds against pathogen and human enzymes; screening of compounds against protozoa, bacteria and mycobacterium in vitro.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences microbiology protozoology
- medical and health sciences clinical medicine pneumology tuberculosis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CF10 3XF CARDIFF
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.