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Deoxyuridine triphosphate nucleotidohydrolase as a drug target for the control of protozoal and bacterial infections

Objective

This proposal concerns the evaluation of the enzyme deoxyuridine troposphere nucleotidohydrolase as a drug target against bacterial, protozoan and mycobacterium infections. The diseases of particular interest are malaria, leishmaniasis, African trypanosomiasis, Changes' disease, bacterial infections and mycobacterium infections such as tuberculosis. This enzyme may also have application as an anticancer target. The enzyme is essential for the viability of the organism and represents a novel drug target. The following is planned: cloning and over expression of the enzyme from key pathogens; crystallisation and x-ray crystallography of the enzymes; drug design using molecular modelling; screening of a large database of compounds to provide novel leads; synthesis of potential inhibitors; screening of compounds against pathogen and human enzymes; screening of compounds against protozoa, bacteria and mycobacterium in vitro.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF WALES CARDIFF
Address
King Edward Vii Avenue, Redwood Building
CF10 3XF Cardiff
United Kingdom

Participants (5)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Calle Serrano 117
Madrid
INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES
Poland
Address
36,Pawinskiego 5A
02-106 Warszawa
MEDIVIR AB
Sweden
Address
7,Lunastigen 7
141 44 Huddinge
SWISS TROPICAL INSTITUTE
Switzerland
Address
Socinstrasse 57
4051 Basel
University of York
United Kingdom
Address
Heslington
York