Deoxyuridine triphosphate nucleotidohydrolase as a drug target for the control of protozoal and bacterial infections

Objective

This proposal concerns the evaluation of the enzyme deoxyuridine troposphere nucleotidohydrolase as a drug target against bacterial, protozoan and mycobacterium infections. The diseases of particular interest are malaria, leishmaniasis, African trypanosomiasis, Changes' disease, bacterial infections and mycobacterium infections such as tuberculosis. This enzyme may also have application as an anticancer target. The enzyme is essential for the viability of the organism and represents a novel drug target. The following is planned: cloning and over expression of the enzyme from key pathogens; crystallisation and x-ray crystallography of the enzymes; drug design using molecular modelling; screening of a large database of compounds to provide novel leads; synthesis of potential inhibitors; screening of compounds against pathogen and human enzymes; screening of compounds against protozoa, bacteria and mycobacterium in vitro.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF WALES CARDIFF

Address

King Edward Vii Avenue, Redwood Building
CF10 3XF Cardiff
United Kingdom

Participants (5)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Calle Serrano 117
Madrid

INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES

Poland

Address

36,Pawinskiego 5A
02-106 Warszawa

MEDIVIR AB

Sweden

Address

7,Lunastigen 7
141 44 Huddinge

SWISS TROPICAL INSTITUTE

Switzerland

Address

Socinstrasse 57
4051 Basel

University of York

United Kingdom

Address

Heslington
York