Prevalidation of novel alternative pharma-/toxicological screening based on yeast expression technology

Objective

The project aims to the revalidation of a novel alternative pharma-/toxicologicalscreening on potassium channels involved in human diseases based on yeast expression. Ion channels conduct the nerve impulses and mediate the effects of many signal molecules. Potassium (K) channels are by far the most diverse group onion channels known and participate in a wide range of physiological responses. Inmost cells they are responsible for maintaining the resting potential. In excitable tissue currents mediated by K channels underlie the depolarisation of the action potential. Severe diseases connected to K channel dysfunction are ventriculartachycardia, hypertension, deafness and metabolic disorders. The yeast-based screening technology will provide a reliable system for pharmacy- /toxicological analysis and a bioassay for rapid identification of chemical and pharmaceutical compounds and has thus the potential to reduce the need for animal experimentation.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN

Address

Regina Pacis Weg 3
Bonn
Germany

Participants (6)

ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

Address

Narodni Tr. 3
111 42 Praha 1

NEUROSEARCH AS

Denmark

Address

Pederstrupvej 93
Ballerup

STEINBEIS TECHNOLOGY TRANSFER CENTER FOR IN-VITRO PHARMACOLOGY AND TOXICOLOGY

Germany

Address

Universitaetsstr. 10
78457 Konstanz

THE UNIVERSITY OF TUEBINGEN

Germany

Address

Wilhelmstrasse 5
72074 Tuebingen

UNIVERSITY OF COPENHAGEN

Denmark

Address

Noerregade 10
1017 Koebenhavn K/copenhaegen

University of York

United Kingdom

Address

Heslington
York