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Prevalidation of novel alternative pharma-/toxicological screening based on yeast expression technology

Objective

The project aims to the revalidation of a novel alternative pharma-/toxicologicalscreening on potassium channels involved in human diseases based on yeast expression. Ion channels conduct the nerve impulses and mediate the effects of many signal molecules. Potassium (K) channels are by far the most diverse group onion channels known and participate in a wide range of physiological responses. Inmost cells they are responsible for maintaining the resting potential. In excitable tissue currents mediated by K channels underlie the depolarisation of the action potential. Severe diseases connected to K channel dysfunction are ventriculartachycardia, hypertension, deafness and metabolic disorders. The yeast-based screening technology will provide a reliable system for pharmacy- /toxicological analysis and a bioassay for rapid identification of chemical and pharmaceutical compounds and has thus the potential to reduce the need for animal experimentation.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
Address
Regina Pacis Weg 3
Bonn
Germany

Participants (6)

ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Narodni Tr. 3
111 42 Praha 1
NEUROSEARCH AS
Denmark
Address
Pederstrupvej 93
Ballerup
STEINBEIS TECHNOLOGY TRANSFER CENTER FOR IN-VITRO PHARMACOLOGY AND TOXICOLOGY
Germany
Address
Universitaetsstr. 10
78457 Konstanz
THE UNIVERSITY OF TUEBINGEN
Germany
Address
Wilhelmstrasse 5
72074 Tuebingen
UNIVERSITY OF COPENHAGEN
Denmark
Address
Noerregade 10
1017 Koebenhavn K/copenhaegen
University of York
United Kingdom
Address
Heslington
York