Objective The project aims to the revalidation of a novel alternative pharma-/toxicologicalscreening on potassium channels involved in human diseases based on yeast expression. Ion channels conduct the nerve impulses and mediate the effects of many signal molecules. Potassium (K) channels are by far the most diverse group onion channels known and participate in a wide range of physiological responses. Inmost cells they are responsible for maintaining the resting potential. In excitable tissue currents mediated by K channels underlie the depolarisation of the action potential. Severe diseases connected to K channel dysfunction are ventriculartachycardia, hypertension, deafness and metabolic disorders. The yeast-based screening technology will provide a reliable system for pharmacy- /toxicological analysis and a bioassay for rapid identification of chemical and pharmaceutical compounds and has thus the potential to reduce the need for animal experimentation. Fields of science natural scienceschemical sciencesinorganic chemistryalkali metalsmedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN EU contribution No data Address Regina Pacis Weg 3 BONN Germany See on map Links Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution No data Address Narodni tr. 3 111 42 PRAHA 1 See on map Total cost No data NEUROSEARCH AS Denmark EU contribution No data Address Pederstrupvej 93 BALLERUP See on map Links Website Opens in new window Total cost No data STEINBEIS TECHNOLOGY TRANSFER CENTER FOR IN-VITRO PHARMACOLOGY AND TOXICOLOGY Germany EU contribution No data Address Universitaetsstr. 10 78457 KONSTANZ See on map Total cost No data THE UNIVERSITY OF TUEBINGEN Germany EU contribution No data Address Wilhelmstrasse 5 72074 TUEBINGEN See on map Total cost No data UNIVERSITY OF COPENHAGEN Denmark EU contribution No data Address Noerregade 10 1017 KOEBENHAVN K/COPENHAEGEN See on map Total cost No data University of York United Kingdom EU contribution No data Address Heslington YORK See on map Links Website Opens in new window Total cost No data
