Objective
Inflammation plays a key role in the pathogenesis of many relevant diseases with major impact on our health system such as rheumatoid arthritis, inflammatory bowel disease, and glaucomatous diseases, acute and chronic transplant injury. Despite the recent development of new ant-inflammatory drugs, however, the present therapeutic opportunities are not satisfactory because of their limited efficacy and numerous side effects. Recently, a novel mechanism of cytoprotection and immunomodulation by over expression of the stress protein home oxygenise-1 (HO-1) was discovered. The network labs have access to new technologies for the rational design of drugs, modification of the mouse genome, gene transfer, signal transudation and disease models that offer excellent opportunities to study the mechanisms of HO-1 over expression including its downstream processes and to develop novel therapeutic drugs for acute and chronic inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesclinical medicinerheumatology
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesgeneticsgenomes
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
10117 BERLIN
Germany