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Targeting heme-oxygenase-1 or downstream processes : a new therapeutic approach for treatment of inflammation.

Objective

Inflammation plays a key role in the pathogenesis of many relevant diseases with major impact on our health system such as rheumatoid arthritis, inflammatory bowel disease, and glaucomatous diseases, acute and chronic transplant injury. Despite the recent development of new ant-inflammatory drugs, however, the present therapeutic opportunities are not satisfactory because of their limited efficacy and numerous side effects. Recently, a novel mechanism of cytoprotection and immunomodulation by over expression of the stress protein home oxygenise-1 (HO-1) was discovered. The network labs have access to new technologies for the rational design of drugs, modification of the mouse genome, gene transfer, signal transudation and disease models that offer excellent opportunities to study the mechanisms of HO-1 over expression including its downstream processes and to develop novel therapeutic drugs for acute and chronic inflammation.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

HUMBOLDT-UNIVERSITAET BERLIN
Address
Schumannstrasse 20/21
10117 Berlin
Germany

Participants (7)

BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING"
Greece
Address
Fleming Street 14-16
16672 Glyfada (Attiki)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
Address
Boulevard Jean Monnet 30
44035 Nantes
FUNDACAO CALOUSTE GULBENKIAN
Portugal
Address
45-A,av.berna 45-A
1000 Lisboa
IMTIX-SANGSTAT S.A.S.
France
Address
Avenue Debourg 58
69007 Lyon
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address

6500 GL Nijmegen
UNIVERSITY OF ERLANGEN-NUREMBERG
Germany
Address
Egerlandstrasse 1
91058 Erlangen
Birkbeck College, University of London
United Kingdom
Address
Malet Street, Bloomsbury
WC1E 7HX London