Targeting heme-oxygenase-1 or downstream processes : a new therapeutic approach for treatment of inflammation.

Objective

Inflammation plays a key role in the pathogenesis of many relevant diseases with major impact on our health system such as rheumatoid arthritis, inflammatory bowel disease, and glaucomatous diseases, acute and chronic transplant injury. Despite the recent development of new ant-inflammatory drugs, however, the present therapeutic opportunities are not satisfactory because of their limited efficacy and numerous side effects. Recently, a novel mechanism of cytoprotection and immunomodulation by over expression of the stress protein home oxygenise-1 (HO-1) was discovered. The network labs have access to new technologies for the rational design of drugs, modification of the mouse genome, gene transfer, signal transudation and disease models that offer excellent opportunities to study the mechanisms of HO-1 over expression including its downstream processes and to develop novel therapeutic drugs for acute and chronic inflammation.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

HUMBOLDT-UNIVERSITAET BERLIN

Address

Schumannstrasse 20/21
10117 Berlin
Germany

Participants (7)

BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING"

Greece

Address

Fleming Street 14-16
16672 Glyfada (Attiki)

CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

France

Address

Boulevard Jean Monnet 30
44035 Nantes

FUNDACAO CALOUSTE GULBENKIAN

Portugal

Address

45-A,av.berna 45-A
1000 Lisboa

IMTIX-SANGSTAT S.A.S.

France

Address

Avenue Debourg 58
69007 Lyon

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Address

6500 GL Nijmegen

UNIVERSITY OF ERLANGEN-NUREMBERG

Germany

Address

Egerlandstrasse 1
91058 Erlangen

Birkbeck College, University of London

United Kingdom

Address

Malet Street, Bloomsbury
WC1E 7HX London