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Targeting heme-oxygenase-1 or downstream processes : a new therapeutic approach for treatment of inflammation.

Objective

Inflammation plays a key role in the pathogenesis of many relevant diseases with major impact on our health system such as rheumatoid arthritis, inflammatory bowel disease, and glaucomatous diseases, acute and chronic transplant injury. Despite the recent development of new ant-inflammatory drugs, however, the present therapeutic opportunities are not satisfactory because of their limited efficacy and numerous side effects. Recently, a novel mechanism of cytoprotection and immunomodulation by over expression of the stress protein home oxygenise-1 (HO-1) was discovered. The network labs have access to new technologies for the rational design of drugs, modification of the mouse genome, gene transfer, signal transudation and disease models that offer excellent opportunities to study the mechanisms of HO-1 over expression including its downstream processes and to develop novel therapeutic drugs for acute and chronic inflammation.

Call for proposal

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Coordinator

HUMBOLDT-UNIVERSITAET BERLIN
EU contribution
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Address
Schumannstrasse 20/21
10117 BERLIN
Germany

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Participants (7)