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Content archived on 2024-06-17

Engineering yeast for efficient expression of heterologous membrane transporters

Objective

Expression of human proteins in a readily usable heterologous system is a powerful mean to study their function and structure and to discover novel targets and therapeutic routes directly associated with the causes of disease. Common yeast is ideal to adapt this technology to the human genome scale. Yet many laboratories have the same fundamental problem - the failure of many membrane proteins (the main target of pharmaceutical products) to be functionally expressed in yeast due to incorrect delivery or maintenance at the plasma membrane. The EFFEXPORT project aims to engineer yeast into a more reliable system for expression of heterologous membrane transporters. The novel yeast strains and associated strategies will be used to develop a new type of screening assay for identifying chemical compounds that act selectively on transporters of interest.

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Call for proposal

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Coordinator

UNIVERSITE LIBRE DE BRUXELLES
EU contribution
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Address
Rue des Pr. Jeener et Brachet, 12
6041 GOSSELIES
Belgium

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Participants (7)