Objective
Some autonomous proviruss show once-and endotheliotropic properties in their natural hosts and will be used as vectors to deliver anti-antigenic and leukocy-te-recruiting and/or activating cytokines. The anti-tumour capacity of these vectors will be evaluated in human and mouse tumour models, in particular endotheliums and highly vascular zed glioblastomas. The tumour targeting of natural proviruses will be further improved by producing parvoviral vectors whose cupids carry at their surface peptides enabling them to bind to specific tumour-displayed markers. Furthermore, parvoviral vectors will be produced, which combine their genuine toxic gene with transgenic coding for either tumour-associated antigens or dendrite cell-recruiting or activating cytokines. These vectors will be tested for their capacity to stimulate tumour antigen presentation by dendrite cells and to elicit strong anti-tumour catatonic T lymphocyte responses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.