Objective
Some autonomous proviruss show once-and endotheliotropic properties in their natural hosts and will be used as vectors to deliver anti-antigenic and leukocy-te-recruiting and/or activating cytokines. The anti-tumour capacity of these vectors will be evaluated in human and mouse tumour models, in particular endotheliums and highly vascular zed glioblastomas. The tumour targeting of natural proviruses will be further improved by producing parvoviral vectors whose cupids carry at their surface peptides enabling them to bind to specific tumour-displayed markers. Furthermore, parvoviral vectors will be produced, which combine their genuine toxic gene with transgenic coding for either tumour-associated antigens or dendrite cell-recruiting or activating cytokines. These vectors will be tested for their capacity to stimulate tumour antigen presentation by dendrite cells and to elicit strong anti-tumour catatonic T lymphocyte responses.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
69120 HEIDELBERG
Germany