Objective
Tumourigenesis may result from a de-regulation of genes that normally control embryonic development. We propose to use simple ascidians and fish embryos as tools to analyse the genetic diversity underlying cell proliferation and death. These embryos have a simple genome, and genes similar to human ones. We will perform a systematic screen for genes expressed in areas of cell proliferation and death. Putative roles for the new gene families will be inferred from expression pattern studies (acquired in a database), and then tested in embryos and cancer cells. In particular, we plan to use a novel and extremely potent generation of antisepses oligonucleotides, with potential therapeutic outcomes. The major goal of this project is therefore, by taking advantage of the use of simple chordate entrys, to identify new types of regulators of human cell proliferation and death, which are good candidates to design anti-cancer drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencescomputer and information sciencesdatabases
- natural sciencesbiological sciencesdevelopmental biology
- medical and health sciencesclinical medicineoncology
- medical and health sciencesclinical medicineembryology
- natural sciencesbiological sciencesgeneticsgenomes
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
91198 GIF SUR YVETTE
France