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Novel genechip technology for simplified detection of molecularly heterogeneous genetic diseases: detection of cystic fibrosis as a model

Objective

The objective is to develop and demonstrate a new gene array technology platform for high-throughput diagnosis of CF and CF-related diseases as a model for other genetic diseases. An integrated magnetic sensor-based gene array will be developed comprising novel giant magneto resistance or tunnel magneto resistance sensors for direct magnetic detection of hybridisation of target DNA-tagged magnetic beads. New CF diagnostic assays will be developed based on oligonucleotide or based-based magnetic sensor array detection of qualitative or quantitative changes in RNA products resulting from either mutations in the CFTR gene (splice site mutations) or possible atypical RNA expression patterns from other genes caused by the presence of an abnormal CFTR gene. Screens for known mutations in the CFTR gene caused by Snips in genomic DNA samples from blood using a novel primer-extension based micro array method will also be developed

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

National Microelectronics Research Center
Address
Prospect Row, Lee Malting
30
Ireland

Participants (7)

FUNDAÇAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA
Portugal
Address
Campo Grande C8
1749-016 Lisboa
INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES
Portugal
Address
Rua Alves Redol 9
1000 Lisboa
INTERUNIVERSITAIR MIKRO-ELEKTRONICA CENTRUM VZW
Belgium
Address
75,Kapeldreef 75
3001 Heverlee
MWG-BIOTECH UK LTD
United Kingdom
Address
Mill Court, Featherstone Road, Wolverton Mill Sout
MK12 5RD Milton Keynes
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Thivon And Levadias Str., St Sofia's Children Hosp
11527 Athens
NATIONAL UNIVERSITY OF IRELAND DUBLIN
Ireland
Address
Our Lady's Hospital For Sick Children, Crumlin
12 Dublin
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Address
Western Road
Cork