Objective The Partners have proposed a new hypothesis whereby vascular endothelial growth factor (VEGF) is arterioprotective in intimae hyperplasic and arteriosclerosis. That cell signalling of the VEGF family, which underlines the production of NO and PGI_2, is the basis of the arterioprotective effect will be elucidated. Peptides will be synthesised and used as probes and as substitutes for the VEGF receptors in functional studies. The peptides will be the basis of future cytoprotective medicines. Rabbit and mice models of VEGF protective functions will be used. Novel VEGF- and PIGF-induced genes will be discovered leading to novel therapies. Transgenic mouse models lacking or expressing mutant forms of the VEGF family of genes will be used to evaluate the vasculoprotective role in intimae hyperplasic and arteriosclerosis. This project will elucidate the mechanisms involved in arterioprotection by VEGF and produce novel arterioprotective therapeutics. Fields of science natural sciencesbiological sciencescell biologycell signalingmedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosis Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Birkbeck College, University of London EU contribution No data Address Malet Street, Bloomsbury WC1E 7HX London United Kingdom See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Belgium EU contribution No data Address Rijvisschestraat 120 9052 ZWIJNAARDE See on map Total cost No data UNIVERSITY OF KUOPIO Finland EU contribution No data Address Savilahdentie 9 1627 KUOPIO See on map Total cost No data University of Ulm Germany EU contribution No data Address Albert-Einstein-Allee 11 89070 Ulm See on map Total cost No data
