Objective
The Partners have proposed a new hypothesis whereby vascular endothelial growth factor (VEGF) is arterioprotective in intimae hyperplasic and arteriosclerosis. That cell signalling of the VEGF family, which underlines the production of NO and PGI_2, is the basis of the arterioprotective effect will be elucidated. Peptides will be synthesised and used as probes and as substitutes for the VEGF receptors in functional studies. The peptides will be the basis of future cytoprotective medicines. Rabbit and mice models of VEGF protective functions will be used. Novel VEGF- and PIGF-induced genes will be discovered leading to novel therapies. Transgenic mouse models lacking or expressing mutant forms of the VEGF family of genes will be used to evaluate the vasculoprotective role in intimae hyperplasic and arteriosclerosis. This project will elucidate the mechanisms involved in arterioprotection by VEGF and produce novel arterioprotective therapeutics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.