Objective In vitro studies, clinical trials and the cure of acute promyelocytic leukemiahave unequivocally demonstrated the cancer therapeutic and cancer preventive action of retinues and resinous. We will generate novel types of legends that activate only a specific function and/or receptor isotope and define itscoregulator interaction pattern. We will identify anti-cancer drugs which exploit the(1) link between retinues and selective-selective TRAIL death signalling,(2) autonomous reined signalling that controls cell differentiation and apoptosis,(3) activation by HDAC or methylamine inhibitors of growth regulation in retinoidnon-responsive cells,(4) crosswalk with other signalling pathways that can prevent chemical carcinogen sis, and(5) anti-viral action. The present consortium combines experts of different disciplines to chemically synthesize, screen and characterize novel ret (x) inroads and investigate the molecular basis of their anticancer action. Fields of science medical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF VIGO Address 36200 Vigo Spain See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address Rue michel ange 3 75794 Paris See on map Links Website Opens in new window GALDERMA RESEARCH AND DEVELOPMENT France EU contribution € 0,00 Address Route des lucioles 635 06902 Sophia antipolis See on map INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address Rue de tolbiac, 101 75654 Paris See on map ISTITUTO NAZIONALE TUMORI CENTROEUROPEO Italy EU contribution € 0,00 Address Via pedemontana occidentale 12 33081 Aviano See on map SECONDA UNIVERSITA DEGLI STUDI DI NAPOLI Italy EU contribution € 0,00 Address Viale beneduce 10 81100 Caserta See on map UNIVERSITÀ DEGLI STUDI DI FERRARA Italy EU contribution € 0,00 Address Via borsari, 46 44100 Ferrara See on map
