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Synthesis and mechanism of action of novel classes of retinoids and rexinoids with antineoplastic activities

Objective

In vitro studies, clinical trials and the cure of acute promyelocytic leukemiahave unequivocally demonstrated the cancer therapeutic and cancer preventive action of retinues and resinous. We will generate novel types of legends that activate only a specific function and/or receptor isotope and define itscoregulator interaction pattern. We will identify anti-cancer drugs which exploit the
(1) link between retinues and selective-selective TRAIL death signalling,
(2) autonomous reined signalling that controls cell differentiation and apoptosis,
(3) activation by HDAC or methylamine inhibitors of growth regulation in retinoidnon-responsive cells,
(4) crosswalk with other signalling pathways that can prevent chemical carcinogen sis, and
(5) anti-viral action. The present consortium combines experts of different disciplines to chemically synthesize, screen and characterize novel ret (x) inroads and investigate the molecular basis of their anticancer action.

Call for proposal

Data not available

Coordinator

UNIVERSITY OF VIGO
Address

36200 Vigo
Spain
 

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
GALDERMA RESEARCH AND DEVELOPMENT
France
Address
Route Des Lucioles 635
06902 Sophia Antipolis
 
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
 
ISTITUTO NAZIONALE TUMORI CENTROEUROPEO
Italy
Address
Via Pedemontana Occidentale 12
33081 Aviano
 
SECONDA UNIVERSITA DEGLI STUDI DI NAPOLI
Italy
Address
Viale Beneduce 10
81100 Caserta
 
UNIVERSITÀ DEGLI STUDI DI FERRARA
Italy
Address
Via Borsari, 46
44100 Ferrara