Objective
Destruction of particular cartilage occurs in rheumatoid arthritis (RA) and osteoarthritis (OA) having an incidence of 1 % and 12% in the population respectively. The resulting disabilities of RA and OA have a major impact on the European economy and health. The novel genetic therapies available have a serious limitation as only targets the inflammatory process, which returns when therapy ceases and does not cure-damaged cartilage. Our hypothesis is: Restoration of joint function could be achieved by long term therapy that is both anti-inflammatory and provides for cartilage differentiation factors that facilitate and induce tissue repair using genetically engineered mesenchymal stem cells (MSC). We will genetically engineer mouse and human MSC using transcription ally regulated lent viral vectors. These cells will attach to damaged cartilage and synthetic matrices, express chondrogenic differentiation or transcription factors and immunosuppressive compounds to enable long-term tissue repair in OA and RA. Engineered cells will be assessed in vitro and in vivo in models of RA and OA. This project will deliver new therapeutics in form of nucleic acids, proteins and engineered cells. These novel technologies would be exploited commercially.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- medical and health sciences clinical medicine rheumatology
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
E1 4NS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.