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Semliki forest virus based therapeutic systems

Objective

SFV based systems are increasingly the virus vector systems of choice for production of recombinant proteins for research, therapy and diagnosis. They have also been used as the basis for vaccines for a number of pathogens and recent studies indicate that they could be important systems for gene therapy and cancer therapy. For each of these uses the current system has limitations, which could be modified by engineering the viral replicas gene and by targeting to specific cell types. Work on SFV systems has been an exclusively European effort and this project will combine the expertise of the principal EU laboratories. The aim is to research, design, engineer, and test and delivers a new generation of SFV systems for research, biotechnology, vaccination, gene therapy and cancer therapy. These systems will have many important uses in biology, medicine and veterinary medicine and make an important contribution to the quality of life in Europe and worldwide.

Call for proposal

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Coordinator

University of Edinburgh
Address
Old College South Bridge
EH1 1HN Edinburgh
United Kingdom

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Participants (6)

BIOPTION AB
Sweden
Address
Haesthagsvaegen 30 A
19163 Sollentuna

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ESTONIAN BIOCENTRE
Estonia
Address
Riia St. 23
51010 Tartu

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KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm

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NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Address
Belfield
Dublin

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THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
Trinity College
2 Dublin

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UNIVERSITY OF HELSINKI
Finland
Address
Yliopistonkatu 4
00014 Helsinki

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