Semliki forest virus based therapeutic systems

Objective

SFV based systems are increasingly the virus vector systems of choice for production of recombinant proteins for research, therapy and diagnosis. They have also been used as the basis for vaccines for a number of pathogens and recent studies indicate that they could be important systems for gene therapy and cancer therapy. For each of these uses the current system has limitations, which could be modified by engineering the viral replicas gene and by targeting to specific cell types. Work on SFV systems has been an exclusively European effort and this project will combine the expertise of the principal EU laboratories. The aim is to research, design, engineer, and test and delivers a new generation of SFV systems for research, biotechnology, vaccination, gene therapy and cancer therapy. These systems will have many important uses in biology, medicine and veterinary medicine and make an important contribution to the quality of life in Europe and worldwide.

Fields of science

• agricultural sciences › veterinary sciences
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• medical and health sciences › clinical medicine › oncology

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

University of Edinburgh

Address

Old College South Bridge
EH1 1HN Edinburgh
United Kingdom

Participants (6)

BIOPTION AB

Sweden

Address

Haesthagsvaegen 30 A
19163 Sollentuna

ESTONIAN BIOCENTRE

Estonia

Address

Riia St. 23
51010 Tartu

KAROLINSKA INSTITUTE

Sweden

Address

Solnavagen 1
171 77 Stockholm

NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

Address

Belfield
Dublin

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN

Ireland

Address

Trinity College
2 Dublin

UNIVERSITY OF HELSINKI

Finland

Address

Yliopistonkatu 4
00014 Helsinki