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Gene mining of metagenomes for novel enzymes and therapeutics

Objective

Microbial diversity is a key element in the search to new, valuable compounds such as enzymes with novel properties for industrial applications or which may lead to new or modified antimicrobials. Only a limited number of microorganisms from the environment can be cultured. Therefore, this project will exploit the vast genetic potential of the unexploited Met genome in a culture-independent process using functional genomic, PCR-based screens and in silicon gene mining. The deification of novel genes coding for plant cell wall degrading enzymes and antimicrobials will be emphasized. Their expression potential in industrially important hosts to give economically relevant yields will be investigated. Altogether, the project will combine the enormous potential of biodiversity with cutting edge screening technology, molecular biology and bio informatics to develop products with high biotechnological or pharmaceutical value.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (7)

COMBINATURE BIOPHARM AG
Germany
Address
Robert-roessle-strasse 10
13125 Berlin
FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS
Greece
Address
Vassilika Vouton
71110 Iraklion
GEORG-AUGUST-UNIVERSITY GOETTINGEN
Germany
Address
Grisebachstrasse 8
37077 Goettingen
NOVOZYMES A/S
Denmark
Address
Kroegshoejvej 36, Bldg. 1 B, Tsch
2880 Bagsvaerd
ROWETT RESEARCH INSTITUTE
United Kingdom
Address
Greenburn Road
AB21 9SB Aberdeen
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Address
Campus De San Juan- Ctra. De Valencia, Km 8,7
03550 San Juan De Alicante
University of East Anglia
United Kingdom
Address
University Plain
NR4 7TJ Norwich