Gene mining of metagenomes for novel enzymes and therapeutics

Objective

Microbial diversity is a key element in the search to new, valuable compounds such as enzymes with novel properties for industrial applications or which may lead to new or modified antimicrobials. Only a limited number of microorganisms from the environment can be cultured. Therefore, this project will exploit the vast genetic potential of the unexploited Met genome in a culture-independent process using functional genomic, PCR-based screens and in silicon gene mining. The deification of novel genes coding for plant cell wall degrading enzymes and antimicrobials will be emphasized. Their expression potential in industrially important hosts to give economically relevant yields will be investigated. Altogether, the project will combine the enormous potential of biodiversity with cutting edge screening technology, molecular biology and bio informatics to develop products with high biotechnological or pharmaceutical value.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (7)

COMBINATURE BIOPHARM AG

Germany

Address

Robert-roessle-strasse 10
13125 Berlin

FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS

Greece

Address

Vassilika Vouton
71110 Iraklion

GEORG-AUGUST-UNIVERSITY GOETTINGEN

Germany

Address

Grisebachstrasse 8
37077 Goettingen

NOVOZYMES A/S

Denmark

Address

Kroegshoejvej 36, Bldg. 1 B, Tsch
2880 Bagsvaerd

ROWETT RESEARCH INSTITUTE

United Kingdom

Address

Greenburn Road
AB21 9SB Aberdeen

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Spain

Address

Campus De San Juan- Ctra. De Valencia, Km 8,7
03550 San Juan De Alicante

University of East Anglia

United Kingdom

Address

University Plain
NR4 7TJ Norwich