Objective
The use of enzymes as biocatalysts is a rapidly developing field of immense academic and industrial interest. Several biocatalysts as lipases and penicillinacylases proved to be optimally suited for the Nan technological production of therapeutic compounds including enantiopure pharmaceuticals. At present, however, these biocatalysts cannot be produced in sufficient amounts and at a reasonable price because traditional production hosts like Bacillus and Aspergillums do not support their correct folding and secretion. This proposal aims at providing absolution to this problem by construction of a Gram-negative secretion host strain with its perils engineered into a compartment optimised for the assembly and folding of complex biocatalysts. The barrier in the secretion pathway imposed byte bacterial outer membrane will be overcome by relaxing the selectivity and specificity of the secretion machinery using Nan biotechnological strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencescatalysisbiocatalysis
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
3584 CA UTRECHT
Netherlands